公开(公告)号：US09642829B2

公开(公告)日：2017-05-09

申请号：US14095757

申请日：2013-12-03

申请人： The University of Hong Kong

发明人： Chaminda Jayampath Seneviratne ,  Yi Tsun Richard Kao ,  Lakshman Perera Samaranayake ,  Kwok Yung Yuen ,  Dan Yang ,  Yu Wang ,  Sze Wah Sarah Wong

IPC分类号： C07D309/34 ,  A61K31/351 ,  A01N43/40 ,  A01N59/00 ,  A61K9/00 ,  A61K9/08

CPC分类号： A61K31/351 ,  A01N43/40 ,  A01N59/00 ,  A61K9/0019 ,  A61K9/08 ,  A01N25/34

摘要： Disclosed herein is a novel antifungal compound, derivatives that are used to treat fungal infections. In a specific embodiment, the compound is a small molecule. In a specific embodiment, the compound described herein inhibits yeast to hypha transition under robust hyphal inducing conditions at lower concentration of the molecule. Also disclosed is a composition comprising the antifungal compound. In a specific embodiment, the composition is a pharmaceutical composition. Also disclosed is a method of treating and/or preventing fungal infection using the disclosed compound. The disclosed compound exhibits antifungal activity against wide range of fungal species at slightly higher concentrations. Antifungal compound disclosed herein is used as anti-biofilm agent against fungal infections.