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公开(公告)号：US20090131447A1
公开(公告)日：2009-05-21
申请号：US11815739
申请日：2006-02-08
申请人： Rajender Kamboj , Michael D. Winther , Robert Fraser , Mikhail Chafeev , Sultan Chowdhury , Jian-Min Fu , Duanjie Hou , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Serguei Sviridov , Kashinath Sadalapure , Shaoyi Sun , Vishnumurthy Kodumuru , Nagasree Chakka , Zaihui Zhang , Melwyn Abreo , Mikhail A. Kondratenko , Daniel F. Harvey , Cindy J. Hudson , Wenbao Li , Chi Tu , Sengen Sun , Mark W. Holladay , Heinz W. Gschwend
发明人： Rajender Kamboj , Michael D. Winther , Robert Fraser , Mikhail Chafeev , Sultan Chowdhury , Jian-Min Fu , Duanjie Hou , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Serguei Sviridov , Kashinath Sadalapure , Shaoyi Sun , Vishnumurthy Kodumuru , Nagasree Chakka , Zaihui Zhang , Melwyn Abreo , Mikhail A. Kondratenko , Daniel F. Harvey , Cindy J. Hudson , Wenbao Li , Chi Tu , Sengen Sun , Mark W. Holladay , Heinz W. Gschwend
IPC分类号： A61K31/501 , A61K31/4436 , A61K31/496 , A61P3/04
CPC分类号： A61K31/64 , A61K31/00 , A61K31/4439 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain.
摘要翻译： 本发明涉及式（I）的SCD-1抑制剂的用途：其中x，y，V，W，G，J，L，M，R2，R3，R5，R5a，R6，R6a，R7， 本文定义R7a，R8和R8a与其他药物治疗组合以治疗不利的体重增加。
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公开(公告)号：US07919484B2
公开(公告)日：2011-04-05
申请号：US11815739
申请日：2006-02-08
申请人： Rajender Kamboj , Michael D. Winther , Robert Fraser , Mikhail Chafeev , Sultan Chowdhury , Jian-Min Fu , Duanjie Hou , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Serguei Sviridov , Kashinath Sadalapure , Shaoyi Sun , Vishnumurthy Kodumuru , Nagasree Chakka , Zaihui Zhang , Melwyn Abreo , Mikhail A. Kondratenko , Daniel F. Harvey , Cindy J. Hudson , Wenbao Li , Chi Tu , Sengen Sun , Mark W. Holladay , Heinz W. Gschwend
发明人： Rajender Kamboj , Michael D. Winther , Robert Fraser , Mikhail Chafeev , Sultan Chowdhury , Jian-Min Fu , Duanjie Hou , Shifeng Liu , Vandna Raina , Mehran Seid Bagherzadeh , Serguei Sviridov , Kashinath Sadalapure , Shaoyi Sun , Vishnumurthy Kodumuru , Nagasree Chakka , Zaihui Zhang , Melwyn Abreo , Mikhail A. Kondratenko , Daniel F. Harvey , Cindy J. Hudson , Wenbao Li , Chi Tu , Sengen Sun , Mark W. Holladay , Heinz W. Gschwend
IPC分类号： A61K31/501 , C07D211/34
CPC分类号： A61K31/64 , A61K31/00 , A61K31/4439 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： This invention is directed to the use of SCD-1 inhibitors of the formula (I): where x, y, V, W, G, J, L, M, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein, in combination with other drug therapies to treat adverse weight gain.
摘要翻译： 本发明涉及式（I）的SCD-1抑制剂的用途：其中x，y，V，W，G，J，L，M，R2，R3，R5，R5a，R6，R6a，R7， 本文定义R7a，R8和R8a与其他药物治疗组合以治疗不利的体重增加。
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公开(公告)号：US20100048584A1
公开(公告)日：2010-02-25
申请号：US12552868
申请日：2009-09-02
申请人： Melwyn Abreo , Daniel F. Harvey , Heinz W. Gschwend , Wenbao Li , Chi Tu , Rajender Kamboj , Michael D. Winther , Vishnumurthy Kodumuru , Cindy J. Hudson , Mikhail A. Kondratenko , Shifeng Liu , Vandna Raina , Serguei Sviridov , Zaihui Zhang , Mehran Seid Bagherzadeh , Shaoyi Sun
发明人： Melwyn Abreo , Daniel F. Harvey , Heinz W. Gschwend , Wenbao Li , Chi Tu , Rajender Kamboj , Michael D. Winther , Vishnumurthy Kodumuru , Cindy J. Hudson , Mikhail A. Kondratenko , Shifeng Liu , Vandna Raina , Serguei Sviridov , Zaihui Zhang , Mehran Seid Bagherzadeh , Shaoyi Sun
IPC分类号： A61K31/496 , C12N9/99 , A61P3/04 , A61P3/00 , C07D401/04 , C07D401/14
CPC分类号： C07D213/71 , A61K31/00 , A61K31/501 , C07D213/75 , C07D213/76
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein x, y, W, V, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中x，y，W，V，R 1 ，R2，R3，R4，R5，R6，R7，R7a，R8，R8a，R9，R9a，R10和R10a在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US07605161B2
公开(公告)日：2009-10-20
申请号：US10566193
申请日：2004-07-29
申请人： Melwyn Abreo , Daniel F. Harvey , Heinz W. Gschwend , Wenbao Li , Chi Tu , Rajender Kamboj , Michael D. Winther , Vishnumurthy Kodumuru , Cindy J. Hudson , Mikhail A. Kondratenko , Shifeng Liu , Vandna Raina , Serguei Sviridov , Zaihui Zhang , Mehran Seid Bagherzadeh , Shaoyi Sun
发明人： Melwyn Abreo , Daniel F. Harvey , Heinz W. Gschwend , Wenbao Li , Chi Tu , Rajender Kamboj , Michael D. Winther , Vishnumurthy Kodumuru , Cindy J. Hudson , Mikhail A. Kondratenko , Shifeng Liu , Vandna Raina , Serguei Sviridov , Zaihui Zhang , Mehran Seid Bagherzadeh , Shaoyi Sun
IPC分类号： A61K31/497 , C07D241/04 , C07D295/00
CPC分类号： C07D213/71 , A61K31/00 , A61K31/501 , C07D213/75 , C07D213/76
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein: W is —O—, —N(R1)—, C(O), S(O)t; (where t is 0, 1 or 2), N(R1)S(O)2, S(O)2N(R1), C(O)N(R1) or N(R1)C(O)N(R1); and V is C(O), C(S), C(O)N(R1)—, C(O)O—, S(O)2—, S(O)2N(R1)— or C(R11)H; and x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中：W是-O - ， - N （R 1） - ，C（O），S（O）t; （其中t为0,1或2），N（R1）S（O）2，S（O）2N（R1），C（O）N（R1）或N（R1）C（O） ）; 并且V是C（O），C（S），C（O）N（R 1） - ，C（O）O-，S（O）2 - ，S（O）2 N（R 1） - 或C ）H; 并且x，y，R1，R2，R3，R4，R5，R6，R7，R7a，R8，R8a，R9，R9a，R10和R10a在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US08153636B2
公开(公告)日：2012-04-10
申请号：US12552868
申请日：2009-09-02
申请人： Melwyn Abreo , Daniel F. Harvey , Heinz W. Gschwend , Wenbao Li , Chi Tu , Rajender Kamboj , Michael D. Winther , Vishnumurthy Kodumuru , Cindy J. Hudson , Mikhail A. Kondratenko , Shifeng Liu , Vandna Raina , Serguei Sviridov , Zaihui Zhang , Mehran Seid Bagherzadeh , Shaoyi Sun
发明人： Melwyn Abreo , Daniel F. Harvey , Heinz W. Gschwend , Wenbao Li , Chi Tu , Rajender Kamboj , Michael D. Winther , Vishnumurthy Kodumuru , Cindy J. Hudson , Mikhail A. Kondratenko , Shifeng Liu , Vandna Raina , Serguei Sviridov , Zaihui Zhang , Mehran Seid Bagherzadeh , Shaoyi Sun
IPC分类号： A61K31/497 , C07D401/00
CPC分类号： C07D213/71 , A61K31/00 , A61K31/501 , C07D213/75 , C07D213/76
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein x, y, W, V, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中x，y，W，V，R 1 ，R2，R3，R4，R5，R6，R7，R7a，R8，R8a，R9，R9a，R10和R10a在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US08383628B2
公开(公告)日：2013-02-26
申请号：US12816076
申请日：2010-06-15
申请人： Melwyn Abreo , Daniel F. Harvey , Mikhail A. Kondratenko , Wenbao Li , Rajender Kamboj , Vishnumurthy Kodumuru , Michael D. Winther , Heinz W. Gschwend , Nagasree Chakka , Shifeng Liu , Serguei Sviridov , Shaoyi Sun
发明人： Melwyn Abreo , Daniel F. Harvey , Mikhail A. Kondratenko , Wenbao Li , Rajender Kamboj , Vishnumurthy Kodumuru , Michael D. Winther , Heinz W. Gschwend , Nagasree Chakka , Shifeng Liu , Serguei Sviridov , Shaoyi Sun
IPC分类号： A61K31/497 , C07D401/00
CPC分类号： C07D401/14 , A61K31/00 , A61K31/444 , A61K31/501 , C07D213/75 , C07D213/76 , C07D213/81 , C07D401/04
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中W，V，x，y，R 1 ，R2，R3，R4，R5，R6，R7，R7a，R8，R8a，R9，R9a，R10和R10a在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US07763618B2
公开(公告)日：2010-07-27
申请号：US10566857
申请日：2004-07-29
申请人： Melwyn Abreo , Daniel F. Harvey , Mikhail A. Kondratenko , Wenbao Li , Rajender Kamboj , Vishnumurthy Kodumuru , Michael D. Winther , Heinz W. Gschwend , Nagasree Chakka , Shifeng Liu , Serguei Sviridov , Shaoyi Sun
发明人： Melwyn Abreo , Daniel F. Harvey , Mikhail A. Kondratenko , Wenbao Li , Rajender Kamboj , Vishnumurthy Kodumuru , Michael D. Winther , Heinz W. Gschwend , Nagasree Chakka , Shifeng Liu , Serguei Sviridov , Shaoyi Sun
IPC分类号： A61K31/497 , C07D241/04 , C07D295/00
CPC分类号： C07D401/14 , A61K31/00 , A61K31/444 , A61K31/501 , C07D213/75 , C07D213/76 , C07D213/81 , C07D401/04
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中W，V，x，y，R 1 ，R2，R3，R4，R5，R6，R7，R7a，R8，R8a，R9，R9a，R10和R10a在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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公开(公告)号：US20100305138A1
公开(公告)日：2010-12-02
申请号：US12816076
申请日：2010-06-15
申请人： Melwyn Abreo , Daniel F. Harvey , Mikhail A. Kondratenko , Wenbao Li , Rajender Kamboj , Vishnumurthy Kodumuru , Michael D. Winther , Heinz W. Gschwend , Nagasree Chakka , Shifeng Liu , Serguei Sviridov , Shaoyi Sun
发明人： Melwyn Abreo , Daniel F. Harvey , Mikhail A. Kondratenko , Wenbao Li , Rajender Kamboj , Vishnumurthy Kodumuru , Michael D. Winther , Heinz W. Gschwend , Nagasree Chakka , Shifeng Liu , Serguei Sviridov , Shaoyi Sun
IPC分类号： A61K31/496 , A61P3/10 , A61P3/04 , A61P17/10 , A61P3/00 , C07D401/04
CPC分类号： C07D401/14 , A61K31/00 , A61K31/444 , A61K31/501 , C07D213/75 , C07D213/76 , C07D213/81 , C07D401/04
摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): wherein W, V, x, y, R1, R2, R3, R4, R5, R6, R7, R7a, R8, R8a, R9, R9a, R10 and R10a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
摘要翻译： 公开了在哺乳动物，优选人中治疗SCD介导的疾病或病症的方法，其中所述方法包括向有需要的哺乳动物施用式（I）化合物：其中W，V，x，y，R 1 ，R2，R3，R4，R5，R6，R7，R7a，R8，R8a，R9，R9a，R10和R10a在本文中定义。 还公开了包含式（I）化合物的药物组合物。
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