公开(公告)号：US20220117888A1

公开(公告)日：2022-04-21

申请号：US17428616

申请日：2020-02-10

Applicant: Ohio State Innovation Foundation

Inventor： Pengfei JIANG ,  Katelyn Elizabeth REILLY ,  Matthew P. OHR ,  John LANNUTTI

IPC: A61K9/00 ,  C08J5/18 ,  C08L67/04 ,  C08L5/08 ,  D01F8/10 ,  D01F8/14 ,  D01D5/00 ,  A61K45/06 ,  A61K39/395

Abstract: The present disclosure relates to compositions, devices, and methods for delivery of protein therapeutics, e.g., intravitreal delivery of a protein therapeutic to the eye. In particular, the present disclosure describes drug-delivery devices for injection into the eye of a subject in need thereof comprising a capsule having a bi-layered wall and a therapeutic agent, wherein the therapeutic agent is initially present within a luminal space of the capsule. Methods of making and using these drug-delivery devices are also described.

公开(公告)号：US20240108584A1

公开(公告)日：2024-04-04

申请号：US18274964

申请日：2022-01-31

Applicant: Ohio State Innovation Foundation

Inventor： John LANNUTTI ,  Fan FAN ,  Andrea TEDESCHI

IPC: A61K9/50 ,  A61K31/197 ,  A61K47/10 ,  A61K47/34 ,  A61P25/28

CPC classification number: A61K9/5031 ,  A61K31/197 ,  A61K47/10 ,  A61K47/34 ,  A61P25/28

Abstract: Described are polymeric microparticles, compositions and method of making and using. The polymeric microparticles can include a polymeric core comprising a first polymer and an active agent susceptible to abuse; and a polymeric shell comprising a second polymer.

公开(公告)号：US20190056364A1

公开(公告)日：2019-02-21

申请号：US15921199

申请日：2018-03-14

Applicant: OHIO STATE INNOVATION FOUNDATION

Inventor： John LANNUTTI ,  Ruipeng XUE

IPC: G01N31/22 ,  G01N21/77 ,  G01N21/64 ,  G01N21/78

Abstract: Nanofiber-based sensors for the rapid detection, identification, and/or quantification of analytes, including gaseous analytes such as oxygen, are provided. The nanofiber-based sensors can comprise core-shell nanofibers. The core-shell nanofibers can comprise (a) a core comprising a first polymer and an sensor dispersed therein; and (b) a shell disposed coaxially around the core, comprising a second polymer.

公开(公告)号：US20160041135A1

公开(公告)日：2016-02-11

申请号：US14777035

申请日：2014-03-17

Applicant: OHIO STATE INNOVATION FOUNDATION

Inventor： John LANNUTTI ,  Ruipeng XUE

IPC: G01N31/22 ,  G01N21/64 ,  G01N21/77

CPC classification number: G01N31/225 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/77 ,  G01N21/783 ,  G01N2021/6432 ,  G01N2021/7786

Abstract: Nanofiber-based sensors for the rapid detection, identification, and/or quantification of analytes, including gaseous analytes such as oxygen, are provided. The nanofiber-based sensors can comprise core-shell nanofibers. The core-shell nanofibers can comprise (a) a core comprising a first polymer and an sensor dispersed therein; and (b) a shell disposed coaxially around the core, comprising a second polymer.

Abstract translation: 提供了用于快速检测，鉴定和/或定量分析物的纳米纤维传感器，包括气体分析物如氧气。 基于纳米纤维的传感器可以包括核 - 壳纳米纤维。 核 - 壳纳米纤维可以包括（a）包含第一聚合物和分散在其中的传感器的芯; 和（b）围绕所述芯同轴设置的外壳，包括第二聚合物。