公开(公告)号：US12019674B2

公开(公告)日：2024-06-25

申请号：US16887036

申请日：2020-05-29

Applicant: NEW YORK UNIVERSITY

Inventor： Jing Wang ,  Prathamesh Kulkarni ,  Eric Robinson

IPC: A61K38/21 ,  G06F16/55 ,  G06F18/21 ,  G06F18/2321 ,  G06N3/04 ,  G06N3/08 ,  G06V10/762 ,  G06V10/764 ,  G06V20/69 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20

CPC classification number: G06F16/55 ,  G06F18/2193 ,  G06F18/2321 ,  G06N3/04 ,  G06N3/08 ,  G06V10/763 ,  G06V10/764 ,  G06V20/693 ,  G06V20/698 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  G06V2201/03

Abstract: A method of treating a subject comprises administering a treatment to a subject identified as having a high probability of distant metastatic recurrence, wherein the probability of distant metastatic recurrence was determined by a process, comprising acquiring at least one image of a tissue sample comprising a plurality of cells, taken from a subject, classifying each of the plurality of cells into categories, dividing the at least one image into a plurality of patches, calculating values for a plurality of morphological features based on the patches, and calculating a distant metastatic recurrence probability based on the values. A computer-implemented method of training a neural network and a system for characterizing a cancer in a subject are also described.

公开(公告)号：US20150125441A1

公开(公告)日：2015-05-07

申请号：US14401202

申请日：2013-05-24

Applicant: NEW YORK UNIVERSITY

Inventor： Jing Wang ,  Edward Ziff

IPC: A61K31/453 ,  A61K45/06 ,  A61K31/4015

Abstract: The present invention provides methods of treating and pharmaceutical compositions useful for treating a mood disorder or depressive symptoms associated with pain, inducing analgesia and treating pain in a subject by administering a pharmaceutically effective amount of an agent capable of one or more of increasing GluA1 level, expression, concentration, or biological activity, increasing calcium permeable AMPA (α amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor (CPAR) level, expression, concentration, or biological activity or potentiating a CPAR current. The agent may be an AMPA potentiator or ampakine. The agent may increase AMPA receptor currents by slowing the deactivation of open channels and may be, for instance, 2-pyrrolidinone, 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluorophenoxyacetamide (PEPA) or LY451646. The agent may also be a protein, RNA or DNA product.

Abstract translation: 本发明提供了治疗药物组合物和药物组合物的方法，所述药物组合物可用于治疗情绪障碍或与疼痛相关的抑郁症状，诱导镇痛和治疗受试者的疼痛，其通过施用药学有效量的能够增加GluA1水平， 表达，浓度或生物活性，增加钙渗透性AMPA（α氨基-3-羟基-5-甲基异恶唑-4-丙酸）受体（CPAR）水平，表达，浓度或生物活性或增强CPAR电流。 该药剂可以是AMPA增效剂或ampakine。 该试剂可以通过减缓开放通道的失活来增加AMPA受体电流，并且可以是例如2-吡咯烷酮，4- [2-（苯基磺酰基氨基）乙硫基] -2,6-二氟苯氧基乙酰胺（PEPA）或LY451646。 该试剂也可以是蛋白质，RNA或DNA产物。

公开(公告)号：US20250061149A1

公开(公告)日：2025-02-20

申请号：US18750510

申请日：2024-06-21

Applicant: NEW YORK UNIVERSITY

Inventor： Jing Wang ,  Prathamesh Kulkarni ,  Eric Robinson

IPC: G06F16/55 ,  G06F18/21 ,  G06F18/2321 ,  G06N3/04 ,  G06N3/08 ,  G06V10/762 ,  G06V10/764 ,  G06V20/69 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20

Abstract: A method of treating a subject comprises administering a treatment to a subject identified as having a high probability of distant metastatic recurrence, wherein the probability of distant metastatic recurrence was determined by a process, comprising acquiring at least one image of a tissue sample comprising a plurality of cells, taken from a subject, classifying each of the plurality of cells into categories, dividing the at least one image into a plurality of patches, calculating values for a plurality of morphological features based on the patches, and calculating a distant metastatic recurrence probability based on the values. A computer-implemented method of training a neural network and a system for characterizing a cancer in a subject are also described.

公开(公告)号：US20200381121A1

公开(公告)日：2020-12-03

申请号：US16887036

申请日：2020-05-29

Applicant: NEW YORK UNIVERSITY

Inventor： Jing Wang ,  Prathamesh Kulkarni ,  Eric Robinson

IPC: G16H50/20 ,  G16H30/40 ,  G16H30/20 ,  G06F16/55 ,  G06N3/08 ,  G06N3/04 ,  G06K9/00 ,  G06K9/62

Abstract: A method of treating a subject comprises administering a treatment to a subject identified as having a high probability of distant metastatic recurrence, wherein the probability of distant metastatic recurrence was determined by a process, comprising acquiring at least one image of a tissue sample comprising a plurality of cells, taken from a subject, classifying each of the plurality of cells into categories, dividing the at least one image into a plurality of patches, calculating values for a plurality of morphological features based on the patches, and calculating a distant metastatic recurrence probability based on the values. A computer-implemented method of training a neural network and a system for characterizing a cancer in a subject are also described.

公开(公告)号：US11664110B2

公开(公告)日：2023-05-30

申请号：US16591150

申请日：2019-10-02

Applicant: New York University

Inventor： Zhe S. Chen ,  Prathamesh M. Kulkarni ,  Zhengdong Xiao ,  Jing Wang

IPC: G16H20/70 ,  G16H40/63 ,  G06N3/08

CPC classification number: G16H20/70 ,  G06N3/08 ,  G16H40/63

Abstract: A method for administering stimulations to a sleeping subject is provided. The method includes obtaining brain wave data generated based on brain wave activity of the subject over a predetermined time frame and determining a spectral power ratio of a spindle band to delta and theta bands of the brain wave data at a time within the predetermined time frame. The spectral power ratio and brain wave data are sent to the input of a pretrained deep neural network to generate a probability score that sleep spindles are being detected in the brain wave activity. The method may continue to obtain brain wave data and analyze the data using the pretrained deep neural network. A determination that sleep spindles are detected may be made when the probability score is above a predetermined threshold score for a predetermined threshold period of time.

公开(公告)号：US10702513B2

公开(公告)日：2020-07-07

申请号：US14401202

申请日：2013-05-24

Applicant: NEW YORK UNIVERSITY

Inventor： Jing Wang ,  Edward Ziff

IPC: A61K31/453 ,  A61K45/06 ,  A61K31/4015 ,  A61K31/275 ,  A61K31/42 ,  A61K31/7105 ,  A61K31/18

Abstract: The present invention provides methods of treating and pharmaceutical compositions useful for treating a mood disorder or depressive symptoms associated with pain, inducing analgesia and treating pain in a subject by administering a pharmaceutically effective amount of an agent capable of one or more of increasing GluA1 level, expression, concentration, or biological activity, increasing calcium permeable AMPA (α amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor (CPAR) level, expression, concentration, or biological activity or potentiating a CPAR current. The agent may be an AMPA potentiator or ampakine. The agent may increase AMPA receptor currents by slowing the deactivation of open channels and may be, for instance, 2-pyrrolidinone, 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluorophenoxyacetamide (PEPA) or LY451646. The agent may also be a protein, RNA or DNA product.