公开(公告)号：US20210269432A1

公开(公告)日：2021-09-02

申请号：US16099398

申请日：2017-05-17

Applicant: MIRATI THERAPEUTICS, INC. ,  ARRAY BIOPHARMA INC.

Inventor： John P. FISCHER ,  Jay Bradford FELL ,  James F. BLAKE ,  Ronald Jay HINKLIN ,  Macedonio J. MEJIA ,  Erik James HICKEN ,  Mark Joseph CHICARELLI ,  John J. GAUDINO ,  Guy P.A. VIGERS ,  Laurence E. BURGESS ,  Matthew Arnold MARX ,  James Gail CHRISTENSEN ,  Matthew Randolf LEE ,  Pavel SAVECHENKOV ,  Henry J. ZECCA ,  Tony P. TANG

IPC: C07D471/04 ,  C07D519/00 ,  A61P35/00

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.