公开(公告)号：US11800858B2

公开(公告)日：2023-10-31

申请号：US16643184

申请日：2018-07-20

Applicant: Korea University Research and Business Foundation

Inventor： Jae-Yong Park ,  Eun Mi Hwang ,  Heh-In Im ,  Chang-Hoon Cho ,  Sangjoon Lee

IPC: A01K67/027 ,  A61K49/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/68 ,  G01N33/50

CPC classification number: A01K67/0276 ,  A61K49/0008 ,  C07K14/47 ,  C07K14/705 ,  G01N33/5088 ,  G01N33/6896 ,  A01K2217/054 ,  A01K2217/075 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0318 ,  A01K2267/0356 ,  G01N2800/302

Abstract: The present invention relates to: A schizophrenia animal model wherein the model is a mouse in which an anoctamin 1 (ANO1) gene is knocked out in cholinergic neurons of a medial habenula; and a preparation method therefor and the like. The schizophrenia animal model according to the present invention targets the medial habenula which is brain tissue playing a major role in the pathogenesis of schizophrenia, and it has been confirmed that when the ANO1 gene is specifically knocked out in the cholinergic neurons of the medial habenula, positive, negative and cognitive symptoms of schizophrenia are observed, thereby confirming that schizophrenia has been induced. Therefore, the animal model of the present invention is expected to be effectively useful in schizophrenia pathogenesis research and therapeutic agent development and screening.