公开(公告)号：US20220228177A1

公开(公告)日：2022-07-21

申请号：US17575460

申请日：2022-01-13

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sang Yup LEE ,  Seon Young PARK

IPC: C12P7/22 ,  C12N1/20 ,  C12N15/11

Abstract: The present invention relates to a recombinant microorganism having enhanced ability to produce lutein and a method of producing lutein using the same, and more specifically, to a recombinant microorganism having enhanced ability to produce lutein, which is obtained by modifying any one or more metabolic pathways, selected from the group consisting of a substrate tunnel, an electron tunnel, and a C5 heme production pathway, in a host cell having ability to produce lutein. Using the highly efficient lutein-producing recombinant microbial strain according to the present invention, it is possible to replace an existing lutein production method that relies on labor-intensive and inefficient plant extraction and to produce lutein in a more environmentally friendly and sustainable way. In addition, the strain development strategy used in the present invention is useful because it may be used to construct a recombinant strain for the efficient production of useful compounds with complex metabolic pathways and to establish an efficient production method, and it may be applied throughout the gradually expanding biochemical market.