Sceletium Extract and Uses Thereof
    1.
    发明申请
    Sceletium Extract and Uses Thereof 有权
    西葫芦提取物及其用途

    公开(公告)号:US20150080447A1

    公开(公告)日:2015-03-19

    申请号:US14331962

    申请日:2014-07-15

    IPC分类号: A61K36/185 A61K31/403

    CPC分类号: A61K36/185 A61K31/403

    摘要: A composition including as an active ingredient an extract of a plant of the family Mesembryanthemaceae with mesembrenol and mesembrenone as the two major alkaloids present. The invention also relates to the use of the composition as a PDE4 inhibitor and as a serotonin-uptake inhibitor, preferably applied in formulations for the use of the composition as a dual serotonin-uptake inhibitor and PDE4 inhibitor. The invention extends to compositions, such as pharmaceutical compositions or compositions used as dietary supplements, the total alkaloid content of which includes at least 80% (w/w) combined content of mesembrenol and mesembrenone, less than 5% (w/w) mesembrine, and at least 7% (w/w) mesembranol.

    摘要翻译: 作为活性成分的组合物,作为两种主要的生物碱,以Mesembrenol和mesembrenone为家族Mesembryanthemaceae植物的提取物。 本发明还涉及组合物作为PDE4抑制剂和5-羟色胺摄取抑制剂的用途,优选用于将组合物用作双重5-羟色胺摄取抑制剂和PDE4抑制剂的制剂中。 本发明延伸到组合物,例如用作膳食补充剂的药物组合物或组合物,其总生物碱含量包括至少80%(w / w)的联合肾上腺素和mesembrenone的组合含量,小于5%(w / w)的mesembrine ,和至少7%(w / w)的间叶吗啉。

    Sceletium extract and uses thereof

    公开(公告)号:US09381220B2

    公开(公告)日:2016-07-05

    申请号:US14331962

    申请日:2014-07-15

    CPC分类号: A61K36/185 A61K31/403

    摘要: A composition including as an active ingredient an extract of a plant of the family Mesembryanthemaceae with mesembrenol and mesembrenone as the two major alkaloids present. The invention also relates to the use of the composition as a PDE4 inhibitor and as a serotonin-uptake inhibitor, preferably applied in formulations for the use of the composition as a dual serotonin-uptake inhibitor and PDE4 inhibitor. The invention extends to compositions, such as pharmaceutical compositions or compositions used as dietary supplements, the total alkaloid content of which includes at least 80% (w/w) combined content of mesembrenol and mesembrenone, less than 5% (w/w) mesembrine, and at least 7% (w/w) mesembranol.