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公开(公告)号：US20160168640A1
公开(公告)日：2016-06-16
申请号：US14937721
申请日：2015-11-10
Applicant: Genentech, Inc.
Inventor： Rajita KHOSLA , Vladimir RAMIREZ-CARROZZI , Tracy STATON , Brian YASPAN , Joseph ARRON , David CHOY , Amy DRESSEN
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6869 , Y02A50/41
Abstract: The invention relates to methods of treating a patient suffering from an IL-33-mediated disorder, such as asthma, comprising administering to the patient an IL-33 axis binding antagonist based on the genotype of the IL1RL1 gene. The invention further relates to methods of determining whether a patient is at increased risk of an IL-33-mediated disorder, as well as methods of determining whether a patient suffering from such a disorder is likely to respond to a treatment comprising an IL-33 axis binding antagonist, based on the genotype of the IL1RL1 gene.
Abstract translation: 本发明涉及治疗患有IL-33介导的病症如哮喘的患者的方法，其包括基于IL1RL1基因的基因型向患者施用IL-33轴结合拮抗剂。 本发明还涉及确定患者是否处于IL-33介导的病症风险增加的方法，以及确定患有这种病症的患者是否可能对包含IL-33介导的病症的治疗有反应的方法 基于IL1RL1基因的基因型。
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Patent Agency Ranking
公开(公告)号：US20180230233A1
公开(公告)日：2018-08-16
申请号：US15893238
申请日：2018-02-09
Applicant: Genentech, Inc.
Inventor： Xiaocheng CHEN , Mark DENNIS , Janet JACKMAN , James T. KOERBER , Mason LU , Henry R. MAUN , Kathila RAJAPAKSA , Saroja RAMANUJAN , Tracy STATON , Lawren WU , Tangsheng YI
Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.
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公开(公告)号：US20180171405A1
公开(公告)日：2018-06-21
申请号：US15525460
申请日：2015-11-10
Applicant: Genentech, Inc.
Inventor： Rajita KHOSLA , Vladimir RAMIREZ-CARROZZI , Tracy STATON , Brian YASPAN , Joseph ARRON , David CHOY , Amy DRESSEN
IPC: C12Q1/6883 , G01N33/68
CPC classification number: C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6869 , Y02A50/41
Abstract: The invention relates to methods of treating a patient suffering from an IL-33-mediated disorder, such as asthma, comprising administering to the patient an IL-33 axis binding antagonist based on the genotype of the /L1RL1gene, the genotype of a polymorphism in genomic vicinity to the IL-33 gene, the expression level of periostin or the expression level of soluble ST2. The invention further relates to methods of determining whether a patient is at increased risk of an IL-33-mediated disorder, as well as methods of determining whether a patient suffering from such a disorder is likely to respond to a treatment comprising an IL-33 axis binding antagonist, based on the genotype of the /L1RL1gene the genotype of a polymorphism in genomic vicinity to the IL-33 gene, the expression level of periostin or the expression level of soluble ST2.
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公开(公告)号：US20240124937A1
公开(公告)日：2024-04-18
申请号：US18329972
申请日：2023-06-06
Applicant: Genentech, Inc.
Inventor： Rajita KHOSLA , Vladimir RAMIREZ-CARROZZI , Tracy STATON , Brian YASPAN , Joseph ARRON , David CHOY , Amy DRESSEN
IPC: C12Q1/6883 , G01N33/68
CPC classification number: C12Q1/6883 , G01N33/6869 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , Y02A50/30
Abstract: The invention relates to methods of treating a patient suffering from an IL-33-mediated disorder, such as asthma, comprising administering to the patient an IL-33 axis binding antagonist based on the genotype of the IL1RL1 gene. The invention further relates to methods of determining whether a patient is at increased risk of an IL-33-mediated disorder, as well as methods of determining whether a patient suffering from such a disorder is likely to respond to a treatment comprising an IL-33 axis binding antagonist, based on the genotype of the IL1RL1 gene.
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公开(公告)号：US20200325248A1
公开(公告)日：2020-10-15
申请号：US16916822
申请日：2020-06-30
Applicant: Genentech, Inc.
Inventor： Xiaocheng CHEN , Mark DENNIS , Janet JACKMAN , James T. KOERBER , Mason LU , Henry R. MAUN , Kathila RAJAPAKSA , Saroja RAMANUJAN , Tracy STATON , Lawren WU , Tangsheng YI
Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.
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公开(公告)号：US20190367637A1
公开(公告)日：2019-12-05
申请号：US16544421
申请日：2019-08-19
Applicant: Genentech, Inc.
Inventor： Xiaocheng CHEN , Mark DENNIS , Janet JACKMAN , James T. KOERBER , Mason LU , Henry R. MAUN , Kathila RAJAPAKSA , Saroja RAMANUJAN , Tracy STATON , Lawren WU , Tangsheng YI
Abstract: The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.
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