公开(公告)号：US20180079806A1

公开(公告)日：2018-03-22

申请号：US15668573

申请日：2017-08-03

Applicant: Genentech, Inc.

Inventor： Junichiro SONODA

IPC: C07K16/22 ,  C07K14/50 ,  A61K38/18

CPC classification number: C07K16/22 ,  A61K38/1825 ,  C07K14/50 ,  C07K2319/00 ,  C07K2319/30

Abstract: The present invention is directed to novel chimeric fibroblast growth factor (FGF) polypeptides, novel DNA encoding chimeric FGF polypeptides, and to the recombinant production of chimeric FGF polypeptides, and to methods, compositions and assays utilizing chimeric FGF polypeptides for the therapeutic treatment of metabolic-related disorders and other conditions, and for producing pharmaceutically active compositions including chimeric FGF polypeptides, the compositions having therapeutic and pharmacologic properties including those associated with the treatment of metabolic-related disorders and other conditions.

公开(公告)号：US20160244525A1

公开(公告)日：2016-08-25

申请号：US14934059

申请日：2015-11-05

Applicant: GENENTECH, INC.

Inventor： Yiyuan YIN ,  Avi ASHKENAZI ,  Paul J. CARTER ,  Mark CHEN ,  Junichiro SONODA

IPC: C07K16/28 ,  C07K16/40 ,  C12P21/02 ,  C07K16/30

CPC classification number: C07K16/2863 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/303 ,  C07K16/3069 ,  C07K16/40 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C12P21/02

Abstract: The invention provides dual specific anti-FGFR2 and FGFR3 (FGFR2/3) antibodies, and compositions comprising and methods of using these antibodies.

Abstract translation: 本发明提供双重特异性抗FGFR2和FGFR3（FGFR2 / 3）抗体，以及包含使用这些抗体的组合物。

公开(公告)号：US20200055896A1

公开(公告)日：2020-02-20

申请号：US16589740

申请日：2019-10-01

Applicant: GENENTECH, INC.

Inventor： Travis William BAINBRIDGE ,  James Andrew ERNST ,  Junichiro SONODA

IPC: C07K7/06 ,  C07K16/40 ,  G01N33/573 ,  G01N33/542 ,  A61K49/00 ,  A61K47/68 ,  C12Q1/37

Abstract: Fluorescence resonance energy transfer (FRET) constructs comprising donor and acceptor fluorophore moieties, and a peptide linking the two, which is a substrate of the endopeptidase fibroblast activation protein (FAP). Also provided are isolated nucleic acids expressing the construct, cell lines comprising the nucleic acids, and kits comprising the construct. Further provided are methods of detecting FAP using the construct via FRET.

公开(公告)号：US20140148388A1

公开(公告)日：2014-05-29

申请号：US13961766

申请日：2013-08-07

Applicant: GENENTECH, INC.

Inventor： Junichiro SONODA

IPC: C07K14/50 ,  C07K16/22

CPC classification number: C07K16/22 ,  A61K38/1825 ,  C07K14/50 ,  C07K2319/00 ,  C07K2319/30

Abstract: The present invention is directed to novel chimeric fibroblast growth factor (FGF) polypeptides, novel DNA encoding chimeric FGF polypeptides, and to the recombinant production of chimeric FGF polypeptides, and to methods, compositions and assays utilizing chimeric FGF polypeptides for the therapeutic treatment of metabolic-related disorders and other conditions, and for producing pharmaceutically active compositions including chimeric FGF polypeptides, the compositions having therapeutic and pharmacologic properties including those associated with the treatment of metabolic-related disorders and other conditions.

Abstract translation: 本发明涉及新的嵌合成纤维细胞生长因子（FGF）多肽，编码嵌合FGF多肽的新型DNA和嵌合FGF多肽的重组产生，以及利用嵌合FGF多肽进行代谢治疗的方法，组合物和测定 相关疾病和其他病症，以及用于产生包含嵌合FGF多肽的药物活性组合物，该组合物具有治疗和药理学性质，包括与治疗代谢相关疾病和其它病症有关的组合物。