公开(公告)号：US11708608B2

公开(公告)日：2023-07-25

申请号：US15525460

申请日：2015-11-10

Applicant: Genentech, Inc.

Inventor： Rajita Khosla ,  Vladimir Ramirez-Carrozzi ,  Tracy Staton ,  Brian Yaspan ,  Joseph Arron ,  David Choy ,  Amy Dressen

IPC: C12Q1/68 ,  C12Q1/6883 ,  G01N33/68

CPC classification number: C12Q1/6883 ,  G01N33/6869 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172 ,  Y02A50/30

Abstract: The invention relates to methods of treating a patient suffering from an IL-33-mediated disorder, such as asthma, comprising administering to the patient an IL-33 axis binding antagonist based on the genotype of the /L1RL1gene, the genotype of a polymorphism in genomic vicinity to the IL-33 gene, the expression level of periostin or the expression level of soluble ST2. The invention further relates to methods of determining whether a patient is at increased risk of an IL-33-mediated disorder, as well as methods of determining whether a patient suffering from such a disorder is likely to respond to a treatment comprising an IL-33 axis binding antagonist, based on the genotype of the /L1RL1gene the genotype of a polymorphism in genomic vicinity to the IL-33 gene, the expression level of periostin or the expression level of soluble ST2.