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公开(公告)号：US10695361B2
公开(公告)日：2020-06-30
申请号：US16265016
申请日：2019-02-01
发明人： Michael O'Neil Hanrahan Clarke , Joy Yang Feng , Robert Jordan , Richard L. Mackman , Adrian S. Ray , Dustin Siegel
IPC分类号： A61K31/706 , A61K31/7056
摘要： Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
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公开(公告)号：US10251904B2
公开(公告)日：2019-04-09
申请号：US15267433
申请日：2016-09-16
发明人： Michael O'Neil Hanrahan Clarke , Joy Yang Feng , Robert Jordan , Richard L. Mackman , Adrian S. Ray , Dustin Siegel
IPC分类号： A61K31/706 , A61K31/7056
摘要： Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
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公开(公告)号：US20190255085A1
公开(公告)日：2019-08-22
申请号：US16265016
申请日：2019-02-01
发明人： Michael O' Neil Hanrahan Clarke , Joy Yang Feng , Robert Jordan , Richard L. Mackman , Adrian S. Ray , Dustin Siegel
IPC分类号： A61K31/706 , A61K31/7056
摘要： Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
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4.发明申请METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS 审中-公开治疗ARENAVIRIDAE和CORONAVIRIDAV病毒感染的方法公开(公告)号：US20170071964A1
公开(公告)日：2017-03-16
申请号：US15267433
申请日：2016-09-16
发明人： Michael O' Neil Hanrahan Clarke , Joy Yang Feng , Robert Jordan , Richard L. Mackman , Adrian S. Ray , Dustin Siegel
IPC分类号： A61K31/706 , A61K45/06
CPC分类号： A61K31/706 , A61K31/7056 , A61K2300/00
摘要： Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
摘要翻译： 其中核苷糖的1'位置被取代。 提供的化合物，组合物和方法特别可用于治疗Lassa病毒和Junin病毒感染。
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公开(公告)号：US20230027727A1
公开(公告)日：2023-01-26
申请号：US17748400
申请日：2022-05-19
发明人： Michael O`Neil Hanrahan Clarke , Joy Yang Feng , Robert Jordan , Richard L. Mackman , Adrian S. Ray , Dustin Siegel
IPC分类号： A61K31/706 , A61K31/7056
摘要： Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I. wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
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公开(公告)号：US11382926B2
公开(公告)日：2022-07-12
申请号：US17222066
申请日：2021-04-05
发明人： Michael O'Neil Hanrahan Clarke , Joy Yang Feng , Robert Jordan , Richard L. Mackman , Adrian S. Ray , Dustin Siegel
IPC分类号： A61K31/706 , A61K31/7056
摘要： Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
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公开(公告)号：US20210393659A1
公开(公告)日：2021-12-23
申请号：US17222066
申请日：2021-04-05
发明人： Michael O`Neil Hanrahan Clarke , Joy Yang Feng , Robert Jordan , Richard L. Mackman , Adrian S. Ray , Dustin Siegel
IPC分类号： A61K31/706 , A61K31/7056
摘要： Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
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公开(公告)号：US11007208B2
公开(公告)日：2021-05-18
申请号：US16863566
申请日：2020-04-30
发明人： Michael O' Neil Hanrahan Clarke , Joy Yang Feng , Robert Jordan , Richard L. Mackman , Adrian S. Ray , Dustin Siegel
IPC分类号： A61K31/7056 , A61K31/706
摘要： Provided are methods for treating Arenaviridae and Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: wherein the 1′ position of the nucleoside sugar is substituted. The compounds, compositions, and methods provided are particularly useful for the treatment of Lassa virus and Junin virus infections.
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