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公开(公告)号：US20030087866A1
公开(公告)日：2003-05-08
申请号：US10223655
申请日：2002-08-20
发明人： Jim A. Wright , Aiping H. Young
IPC分类号： A61K048/00 , C12N015/85
CPC分类号： A61K38/44 , A61K48/00 , C12Y117/04001 , Y02A50/471
摘要： The present invention provides a method of modulating the malignant properties of a cell in a human or other mammal by contacting a neoplastic cell with a growth modulating amount of an expressible nucleic acid sequence for ribonucleotide reductase R1 of the mammal. The present invention also provides and uses a growth modulating amount of the ribonucleotide reductase R1 protein or biologically active peptide to modulate the malignant properties of a cell in a human or other mammal. The method provides for a generally elevated expression of the R1 component of mammalian ribonucleotide reductase. The expressible nucleic acid sequence can be in the form of a vector for gene therapy.
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2.发明申请Antitumor antisense sequences directed against R1 and R2 components of ribonucleotide reductase 失效针对核糖核苷酸还原酶的R1和R2组分的抗肿瘤反义序列公开(公告)号：US20040009948A1
公开(公告)日：2004-01-15
申请号：US10447136
申请日：2003-05-29
发明人： Jim A. Wright , Aiping H. Young
IPC分类号： A61K048/00 , C07H021/02
CPC分类号： C12N15/1137 , A61K38/00 , C07K2319/00 , C12N9/0093 , C12N2310/111 , C12N2310/315 , C12N2799/027
摘要： Compounds and methods for modulating cell proliferation, preferably inhibiting the proliferation of tumor cells are described. Compounds that may be used to modulate cell proliferation include antisense oligonucleotides complementary to regions of the mammalian ribonucleotide reductase genes.
摘要翻译： 描述了调节细胞增殖，优选抑制肿瘤细胞增殖的化合物和方法。 可用于调节细胞增殖的化合物包括与哺乳动物核糖核苷酸还原酶基因区域互补的反义寡核苷酸。
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3.发明申请Insulin-like growth factor II antisense oligonucleotide sequences and methods of using same to modulate cell growth 审中-公开胰岛素样生长因子II反义寡核苷酸序列及其使用方法来调节细胞生长公开(公告)号：US20020187954A1
公开(公告)日：2002-12-12
申请号：US10125181
申请日：2002-04-17
发明人： Jim A. Wright , Aiping H. Young , Yoon S. Lee
IPC分类号： A61K048/00
CPC分类号： C12N15/1136 , A61K38/00 , C12N2310/111 , C12N2310/315
摘要： This invention relates to oligonucleotides complementary to the IGF-II genes which modulate tumor cell growth in mammals This invention is also related to methods of using such compounds in inhibiting the growth of tumor cells in mammals This invention also relates to pharmaceutical compositions comprising a pharmaceutically acceptable excipient and an effective amount of a compound of this invention.
摘要翻译： 本发明涉及与调节哺乳动物肿瘤细胞生长的IGF-II基因互补的寡核苷酸本发明还涉及使用这些化合物抑制哺乳动物肿瘤细胞生长的方法。本发明还涉及包含药学上可接受的药物组合物 赋形剂和有效量的本发明化合物。
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