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公开(公告)号：US20100241404A1
公开(公告)日：2010-09-23
申请号：US12661491
申请日：2010-03-17
CPC分类号： G06F19/3437 , G06F19/00 , G06F19/321 , G16H10/60 , G16H50/50
摘要： A noninvasive patient-specific method is provided to aid in the analysis, diagnosis, prediction or treatment of hemodynamics of the cardiovascular system of a patient. Coronary blood flow and pressure can be predicted using a 3-D patient image-based model that is implicitly coupled with a model of at least a portion of the remaining cardiovascular system. The 3-D patient image-based model includes at least a portion of the thoracic aorta and epicardial coronaries of the patient. The shape of one or more velocity profiles at the interface of the models is enforced to control complex flow features of recirculating or retrograde flow thereby minimizing model instabilities and resulting in patient-specific predictions of coronary flow rate and pressure. The invention allows for patient-specific predictions of the effect of different or varying physiological states and hemodynamic benefits of coronary medical interventions, percutaneous coronary interventions and surgical therapies.
摘要翻译： 提供非侵入性患者特异性方法来帮助分析，诊断，预测或治疗患者心血管系统的血液动力学。 可以使用与至少一部分剩余心血管系统的模型隐含耦合的基于3-D患者图像的模型来预测冠状动脉血流和压力。 3-D患者基于图像的模型包括患者的胸主动脉和心外膜冠状动脉的至少一部分。 模型界面处的一个或多个速度分布的形状被强制以控制循环或逆行流的复杂流动特征，从而最小化模型不稳定性，并导致患者对冠状动脉血流速率和压力的预测。 本发明允许患者特异性预测冠状动脉介入治疗，经皮冠状动脉介入治疗和手术治疗的不同或不同生理状态和血液动力学益处的影响。
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公开(公告)号：US09405886B2
公开(公告)日：2016-08-02
申请号：US12661491
申请日：2010-03-17
CPC分类号： G06F19/3437 , G06F19/00 , G06F19/321 , G16H10/60 , G16H50/50
摘要： A noninvasive patient-specific method is provided to aid in the analysis, diagnosis, prediction or treatment of hemodynamics of the cardiovascular system of a patient. Coronary blood flow and pressure can be predicted using a 3-D patient image-based model that is implicitly coupled with a model of at least a portion of the remaining cardiovascular system. The 3-D patient image-based model includes at least a portion of the thoracic aorta and epicardial coronaries of the patient. The shape of one or more velocity profiles at the interface of the models is enforced to control complex flow features of recirculating or retrograde flow thereby minimizing model instabilities and resulting in patient-specific predictions of coronary flow rate and pressure. The invention allows for patient-specific predictions of the effect of different or varying physiological states and hemodynamic benefits of coronary medical interventions, percutaneous coronary interventions and surgical therapies.
摘要翻译： 提供非侵入性患者特异性方法来帮助分析，诊断，预测或治疗患者心血管系统的血液动力学。 可以使用与至少一部分剩余心血管系统的模型隐含耦合的基于3-D患者图像的模型来预测冠状动脉血流和压力。 3-D患者基于图像的模型包括患者的胸主动脉和心外膜冠状动脉的至少一部分。 模型界面处的一个或多个速度分布的形状被强制以控制循环或逆行流的复杂流动特征，从而最小化模型不稳定性，并导致患者对冠状动脉血流速率和压力的预测。 本发明允许患者特异性预测冠状动脉介入治疗，经皮冠状动脉介入治疗和手术治疗的不同或不同生理状态和血液动力学益处的影响。
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