公开(公告)号：US11020490B2

公开(公告)日：2021-06-01

申请号：US16437047

申请日：2019-06-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ian S. Young ,  Sha Lou ,  Sanjeev Gangwar

IPC: A61K47/00 ,  A61K47/68 ,  C07K5/10

Abstract: In antibody-drug conjugates having tubulysin analog as the warhead, according to formula (III) the acetate group in the Tuv subunit (dotted box) demonstrates improved stability against hydrolytic cleavage.

公开(公告)号：US20190388553A1

公开(公告)日：2019-12-26

申请号：US16437047

申请日：2019-06-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ian S. Young ,  Sha Lou ,  Sanjeev Gangwar

IPC: A61K47/68 ,  C07K5/10

Abstract: In antibody-drug conjugates having tubulysin analog as the warhead, according to formula (III) the acetate group in the Tuv subunit (dotted box) demonstrates improved stability against hydrolytic cleavage.