公开(公告)号：US3892628A

公开(公告)日：1975-07-01

申请号：US31661272

申请日：1972-12-19

Applicant: BAXTER LABORATORIES INC

Inventor： THORNE GALE H ,  WOOD ORIN LEW ,  KNUDSON KAY L

IPC: A61M1/32 ,  C12K9/00

CPC classification number: A61M1/32

Abstract: Apparatus and method of preserving life organs, the apparatus having an organ container in which the organ may be subjected to elevated pressure, a pump pulsatilely delivering perfusate into the organ and an oxygenator to oxygenate the perfusate effluent from the organ. A constant pressure bias maintains a minimum pressure on the perfusate between pulses. A fluid flow control system delivers driving fluid in a pulsed manner to the pump at a selected rate and at selected pulse duration. The method includes delivering pulsed oxygenated perfusate to the organ and uniformly conducting perfusate away from the organ and providing a constant pressure bias on the perfusate. Loss or gain of liquid volume caused by waste secretion by the organ is compensated for.

Abstract translation: 保存生命器官的装置和方法，所述装置具有器官可能受到升高的压力的器官容器，将脉冲地输送灌注液的泵送入器官，以及使来自器官的灌注液流出物的氧合器。 恒定压力偏压保持脉冲之间灌注液的最小压力。 流体流量控制系统以脉冲方式将驱动流体以选定的速率和选定的脉冲持续时间输送到泵。 该方法包括将脉冲氧化灌注液递送至器官并将器官均匀地导入灌注液并在灌注液上提供恒定的压力偏压。 由器官的废物分泌引起的液体体积的损失或增益得到补偿。