公开(公告)号：US3749765A

公开(公告)日：1973-07-31

申请号：US3749765D

申请日：1971-06-15

Applicant: BAXTER LABORATORIES INC

Inventor： BERGER A ,  BORGAES E

IPC: A61K31/505 ,  A61K27/00

CPC classification number: A61K31/505 ,  Y10S514/823

Abstract: URACIL THIOPSEUDOUREAS HAVING THE GENERAL FORMULA

2,4-DI(O=),1,3-DI(CH3-),6-(R-NH-C(-S-R'')=N-)-1,2,3,4-

TETRAHYDROPYRIMIDINE

WHEREIN R AND R'' ARE EACH INDEPENDENTLY SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYL HAVING FROM 1 TO ABOUT 3 CARBON ATOMS, ALLYL AND METHALLYL, AND THE PHARMECEUTICALLY ACCEPTABLE ACID SALTS THEREOF, FOR EXAMPLE, 1-ALLYL - 3 - (2'',4''-DIKETO - 1'',2'',3'',4'' - TETRAHYDROPYRIMIDIN - 6 - YL) - 1'',2'',3'' - TRIMETHYL - 2 - THIOPSEUDOUREA, ARE PHARMACEUTICALLY ADMINISTERED TO ANIMALS GIVEN AN OVERDOSE OF BARBITURATE FOR REVIVING SAID ANIMALS.

公开(公告)号：US3772290A

公开(公告)日：1973-11-13

申请号：US3772290D

申请日：1971-11-18

Applicant: BAXTER LABORATORIES INC

Inventor： BERGER A ,  BORGAES E

IPC: C07D513/04 ,  C07D99/10

CPC classification number: C07D513/04 ,  Y10S514/812

Abstract: THE METHOD OF MAKING THIAZOLOPYRIMIDINES BY REACTION OF 6-AMINO-1,3-DIMETHYLURACIL WITH ALKYL ISOTHIOCYANATE AND DIMETHYLSULFOXIDE AT REFLUX TEMPERATURE.

公开(公告)号：US3761478A

公开(公告)日：1973-09-25

申请号：US3761478D

申请日：1971-12-06

Applicant: BAXTER LABORATORIES INC

Inventor： BERGER A ,  BORGAES E

IPC: C07D239/54 ,  C07D239/545 ,  C07D51/38

CPC classification number: C07D239/545

Abstract: D R A W I N G
ammoni WHEREIN R is selected from the group consisting of lower alkyl having from one to four carbon atoms, allyl, cyclohexyl and 2-methylphenyl. Said compounds are useful central nervous system anti-depressants.


Uracil ureas having the general formula

Abstract translation: 具有通式为R 5选自具有1至4个碳原子的低级烷基，烯丙基，环己基和2-甲基苯基的尿嘧啶脲。 所述化合物是有用的中枢神经系统抗抑郁剂。

公开(公告)号：US3755326A

公开(公告)日：1973-08-28

申请号：US3755326D

申请日：1971-12-06

Applicant: BAXTER LABORATORIES INC

Inventor： BERGER A ,  BORGAES E

IPC: C07D239/54 ,  C07D239/56 ,  C07D51/38

CPC classification number: C07D239/56 ,  C07D239/54 ,  Y10S514/823

Abstract: WHEREIN X is selected from the group consisting of O and S, and wherein R is selected from the group consisting of lower alkyl having from one to four carbon atoms, allyl, methallyl and phenyl. Said compounds are useful as central nervous system antidepressants.

Uracil thioureas having the general formula

Abstract translation: 具有通式WHEREIN X的尿嘧啶硫脲选自O和S，其中R选自具有1至4个碳原子的低级烷基，烯丙基，甲代烯丙基和苯基。 所述化合物可用作中枢神经系统抗抑郁剂。

公开(公告)号：US3745217A

公开(公告)日：1973-07-10

申请号：US3745217D

申请日：1971-11-18

Applicant: BAXTER LABORATORIES INC

Inventor： BERGER A ,  BORGAES E

IPC: C07D513/04 ,  A61K27/00

CPC classification number: C07D513/04

Abstract: THIAZOLOPYRIMIDINES HAVING THE GENERAL FORMULA

2-(R-NH-),5,7-DI(O=),4,6-DI(CH3-)-4,5,6,7-TETRAHYDRO-

THIAZOLO(4,5-D)PYRIMIDINE

WHEREIN R IS SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYL HAVING FROM 1 TO ABOUT 4 CARBON ATOMS AND ALLYL, FOR EXAMPLE, 4,6-DIMETHYL-2-N-PROPYLAMINOTHIAZOLO-(4,5DL-PYRIMIDINE-5,7-DIONE, ARE PHARMACEUTICALLY ADMINISTERED TO ANIMALS GIVEN AN OVERDOSE OF BARBITURATE FOR REVIVING SAID ANIMALS.

公开(公告)号：US3769287A

公开(公告)日：1973-10-30

申请号：US3769287D

申请日：1971-11-18

Applicant: BAXTER LABORATORIES INC

Inventor： BERGER A ,  BORGAES E

IPC: C07D513/04 ,  C07D99/10

CPC classification number: C07D513/04

Abstract: THE METHOD OF MAKING THIAZOLOPYRIMIDINES BY REACTION OF URACIL THIOUREAS WITH HYDROGEN PEROXIDE, FOR EXAMPLE, 1-ALLYL-3-(2,4-DIKETO-1,3-DIMETHYL-1,2,3,4-TETRAHYDROPYRIMIDIN-6-YL)-2 -THIOUREA IS REACTED WITH HYDROGEN PEROXIDE TO YIELD 2-ALLYLAMINO-4,6-DIMETHYL-THIAZOLO(4,5-D) PYRIMIDINE-5,7-DIONE.

公开(公告)号：US3749783A

公开(公告)日：1973-07-31

申请号：US3749783D

申请日：1971-12-06

Applicant: BAXTER LABORATORIES INC

Inventor： BERGER A ,  BORGAES E

IPC: A61K31/505 ,  A61K27/00

CPC classification number: A61K31/505

Abstract: URACIL THIOUREAS HAVING THE GENREAL FORMULA

2-(X=),4-(O=),1,3-DI(CH3-),6-(R-NH-C(=S)-NH-)-1,2,3,4-

TETRAHYDROPYRIMIDINE

WHEREIN X IS SELECTED FROM THE GROUP CONSISTING OF O AND S, AND WHEREIN R IS SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYL HAVING FROM 1 TO ABOUT 4 CARBON ATOMS, ALLYL, METHALLYL AND PHENYL, FOR EXAMPLE, 1-(2-DIKETO1,3 - DIMETHYL-1,2,3,4-TETRAHYDROPYRIMIDIN-6-YL)-3-METHYL2-THIOUREA, ARE PHARMACEUTICALLY ADMINSITERED TO ANIMALS GIVEN AN OVERDOSE OF BARBITURATE FOR REVIVING SAID ANIMALS.

公开(公告)号：US3749782A

公开(公告)日：1973-07-31

申请号：US3749782D

申请日：1971-12-06

Applicant: BAXTER LABORATORIES INC

Inventor： BERGER A ,  BORGAES E

IPC: A61K31/505 ,  A61K27/00

CPC classification number: A61K31/505

Abstract: URACIL UREAS HAVING THE GENERAL FORMULA

2,4-DI(O=),1,3-DI(CH3-),6-(R-NH-CO-NH-)-1,2,3,4-TETRA-

HYDROPYRIMIDINE

WHEREIN R IS SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYL HAVING FROM 1 TO 4 CARBON ATOMS, ALLYL, CYCLOHEXYL AND 2-METHYLPHENYL, FOR EXAMPLE, 1 - (2,4 - DIKETO-1,3DIMETHYL-1,2,3,4-TETRAHYDROPYRIMIDIN - 6 - YL) - 3 - ETHYLUREA, ARE PHARMACEUTICALLY ADMINISTERED TO ANIMALS GIVEN AN OVERDOSE OF BARBITRUATE FOR REVIVING SAID ANIMALS.