公开(公告)号：US20170172988A1

公开(公告)日：2017-06-22

申请号：US15392963

申请日：2016-12-28

Applicant: Array BioPharma Inc.

Inventor： Brian J. Tunquist ,  Duncan H. Walker ,  Richard D. Woessner

IPC: A61K31/433

CPC classification number: A61K31/433 ,  A61K31/00

Abstract: Methods of treating diseases caused by cell division or that are treated by inhibiting mitosis by administering two doses of an inhibitor of mitosis between the biologically effective dose and the maximum tolerated dose in a dosing cycle that allows for the recovery or subsiding of side effects, wherein the second dose is administered 24 to 48 hours after the first dose.

公开(公告)号：US20250152560A1

公开(公告)日：2025-05-15

申请号：US18838130

申请日：2023-02-13

Applicant: OnKure, Inc. ,  Array BioPharma Inc.

Inventor： Anthony D. Piscopio ,  Patrice Anne Lee ,  James Winkler ,  Richard D. Woessner

IPC: A61K31/429 ,  A61K31/4184 ,  A61K31/506 ,  A61P35/00

Abstract: A method of treating cancer in a subject in need thereof, wherein the method comprises administration of therapeutically effective amounts of OKI-179 and binimetinib or a pharmaceutically acceptable salt thereof, or administration of therapeutically effective amounts of OKI-179, binimetinib or a pharmaceutically acceptable salt thereof, and encorafenib or a pharmaceutically acceptable salt thereof according to the dosing schedules described herein.

公开(公告)号：US20180338958A1

公开(公告)日：2018-11-29

申请号：US16000756

申请日：2018-06-05

Applicant: Array BioPharma Inc.

Inventor： Brian J. Tunquist ,  Duncan HL. Walker ,  Richard D. Woessner

IPC: A61K31/433 ,  A61K31/00

Abstract: Methods of treating diseases caused by cell division or that are treated by inhibiting mitosis by administering two doses of an inhibitor of mitosis between the biologically effective dose and the maximum tolerated dose in a dosing cycle that allows for the recovery or subsiding of side effects, wherein the second dose is administered 24 to 48 hours after the first dose.