公开(公告)号：US20210269455A1

公开(公告)日：2021-09-02

申请号：US17069224

申请日：2020-10-13

Applicant: Array BioPharma Inc.

Inventor： Eli Wallace ,  George Topalov ,  Joseph Lyssikatos ,  Alexandre Buckmelter ,  Qian Zhao

IPC: C07D498/10 ,  C07D239/94 ,  C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  A61P29/00 ,  A61P35/00 ,  C07D498/04

Abstract: The invention includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

公开(公告)号：US10221194B2

公开(公告)日：2019-03-05

申请号：US15606928

申请日：2017-05-26

Applicant: ARRAY BIOPHARMA INC.

Inventor： Eli Wallace ,  Joseph Lyssikatos ,  George Topalov ,  Alexandre Buckmelter ,  Qian Zhao

IPC: C07D239/94 ,  C07D498/10 ,  C04B35/632 ,  C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D498/04 ,  A61K31/517 ,  A61P35/04

Abstract: The invention relates to compounds of Formula 11, and to pharmaceutically acceptable acid addition salts thereof, wherein R1—R3, R6, and X have any of the values defined in the specification. The compounds are suitable as synthetic intermediates for preparing imaging tools.

公开(公告)号：US20190161500A1

公开(公告)日：2019-05-30

申请号：US16264194

申请日：2019-01-31

Applicant: Array BioPharma Inc.

Inventor： Eli Wallace ,  George Topalov ,  Joseph Lyssikatos ,  Alexandre Buckmelter ,  Qian Zhao

IPC: C07D498/10 ,  C07D401/12 ,  C07D417/14 ,  C07D413/14 ,  C07D239/94 ,  C07D413/12 ,  C04B35/632 ,  C07D498/04

Abstract: The invention includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

公开(公告)号：US11174273B2

公开(公告)日：2021-11-16

申请号：US16264194

申请日：2019-01-31

Applicant: Array BioPharma Inc.

Inventor： Eli Wallace ,  George Topalov ,  Joseph Lyssikatos ,  Alexandre Buckmelter ,  Qian Zhao

IPC: A61K31/517 ,  C07D498/10 ,  C07D239/94 ,  C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D498/04 ,  A61P35/00 ,  A61P29/00

Abstract: The invention includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

公开(公告)号：US20170260202A1

公开(公告)日：2017-09-14

申请号：US15606928

申请日：2017-05-26

Applicant: ARRAY BIOPHARMA INC.

Inventor： Eli Wallace ,  George Topalov ,  Joseph Lyssikatos ,  Alexandre Buckmelter ,  Qian Zhao

IPC: C07D498/10 ,  C07D498/04 ,  C07D417/14 ,  C07D413/12 ,  C07D401/12 ,  C07D239/94 ,  C04B35/632 ,  C07D413/14

CPC classification number: C07D498/10 ,  C04B35/632 ,  C07D239/94 ,  C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D498/04

Abstract: This invention provides compounds of Formula 11:

公开(公告)号：US20210284656A9

公开(公告)日：2021-09-16

申请号：US16264194

申请日：2019-01-31

Applicant: Array BioPharma Inc.

Inventor： Eli Wallace ,  George Topalov ,  Joseph Lyssikatos ,  Alexandre Buckmelter ,  Qian Zhao

IPC: C07D498/10 ,  C07D401/12 ,  C07D417/14 ,  C07D413/14 ,  C07D239/94 ,  C07D413/12 ,  C04B35/632 ,  C07D498/04

Abstract: The invention includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.