公开(公告)号：US20220282219A1

公开(公告)日：2022-09-08

申请号：US17634766

申请日：2020-08-12

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Mo Reza Ebrahimkhani ,  Jeremy Velazquez ,  Samira Kiani ,  Ryan Patrick LeGraw

IPC: C12N5/0789 ,  C12N5/071 ,  C07K14/47 ,  A61K35/28

Abstract: The present disclosure relates to methods for expanding populations of hematopoietic stem cells (HSCs) using a genetically engineered human fetal liver niche and compositions of purified ex vivo expanded HSCs. Also provided herein are methods of using such expanded HSC cell populations for clinical applications including allogeneic hematopoietic stem cell transplantation and for drug discovery and modeling human liver development.

公开(公告)号：US20210254012A1

公开(公告)日：2021-08-19

申请号：US16973421

申请日：2019-06-10

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY ,  The Johns Hopkins University

Inventor： Samira Kiani ,  Mo Reza Ebrahimkhani ,  Jeremy Velazquez ,  Ryan LeGraw ,  Patrick Cahan

IPC: C12N5/071 ,  C12N15/86 ,  G01N33/50 ,  A61K35/407 ,  C12N15/90

Abstract: The present disclosure relates to synthetic liver organoids and methods of using such synthetic liver organoids for various applications including drug discovery and modeling human liver development. In particular, provided herein are methods of producing and using synthetic mature liver organoids comprising mature, functional cells found in the human liver.