公开(公告)号：US20230279399A1

公开(公告)日：2023-09-07

申请号：US18007560

申请日：2021-06-03

Applicant: Amgen Inc.

Inventor： Daniel C. H. LIN ,  Michael OLLMANN ,  Justin K. MURRAY ,  Bradley J. HERBERICH ,  Amrita DAS ,  Patrick COLLINS ,  Oliver HOMANN

IPC: C12N15/113

CPC classification number: C12N15/1137 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/315 ,  C12N2310/11

Abstract: The present invention relates to RNAi constructs for reducing expression of the HSD17B13 gene. Methods of using such RNAi constructs to treat or prevent liver disease, nonalcoholic fatty liver disease (NAFLD) are also described.