公开(公告)号：US20240254100A1

公开(公告)日：2024-08-01

申请号：US17632333

申请日：2020-08-03

Applicant: AMGEN INC.

Inventor： Nuria A. TAMAYO ,  Matthew Richard KALLER ,  Thomas T. NGUYEN ,  Nobuko NISHIMURA ,  Qiufen May XUE ,  John Gordon ALLEN

IPC: C07D401/04 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/541 ,  C07D241/20 ,  C07D417/14

CPC classification number: C07D401/04 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/541 ,  C07D241/20 ,  C07D417/14

Abstract: Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

公开(公告)号：US20220372018A1

公开(公告)日：2022-11-24

申请号：US17632334

申请日：2020-08-03

Applicant: AMGEN INC.

Inventor： Nuria A. TAMAYO ,  Abhisek BANERJEE ,  Jian Jeffrey CHEN ,  Matthew Richard KALLER ,  Thomas T. NGUYEN ,  Nobuko NISHIMURA ,  Qiufen May XUE ,  John Gordon ALLEN ,  Michael J. FROHN

IPC: C07D401/14 ,  C07D401/04 ,  C07D405/14 ,  C07D413/14

Abstract: Amide compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

公开(公告)号：US20220289724A1

公开(公告)日：2022-09-15

申请号：US17632330

申请日：2020-08-03

Applicant: AMGEN INC.

Inventor： Nuria A. TAMAYO ,  Abhisek BANERJEE ,  Jian Jeffrey CHEN ,  Matthew Paul BOURBEAU ,  Matthew Richard KALLER ,  Jonathan Dante LOW ,  Ana Elena MINATTI ,  Thomas T. NGUYEN ,  Nobuko NISHIMURA ,  Liping H. PETTUS ,  Mary Catherine WALTON ,  Qiufen May XUE ,  John Gordon ALLEN

IPC: C07D405/12 ,  C07D221/20 ,  C07D401/12 ,  C07D409/12 ,  C07D413/12

Abstract: Amide compounds of formula (I): and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of Kinesin Motor Protein KIF18A, such as cancer, psoriasis, atopic dermatitis, an autoimmune disorder, or inflammatory bowel disease, and the like.