公开(公告)号：US10941182B2

公开(公告)日：2021-03-09

申请号：US15317911

申请日：2015-06-10

Applicant: AMGEN INC.

Inventor： Jerry Ryan Holder ,  Gayathri Swaminath ,  Michael J. Frohn ,  Brian Alan Lanman ,  Anthony B. Reed ,  Leslie P. Miranda ,  John G. Allen ,  Alexander J. Pickrell ,  Aaron C. Siegmund ,  Lewis D. Pennington ,  Bryant Yang

IPC: C07K7/08 ,  A61K38/10 ,  C07K14/47 ,  A61K47/54 ,  A61K47/60 ,  A61K38/00

Abstract: The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.

公开(公告)号：US20170107255A1

公开(公告)日：2017-04-20

申请号：US15317911

申请日：2015-06-10

Applicant: AMGEN INC.

Inventor： Jerry Ryan HOLDER ,  Gayathri SWAMINATH ,  Michael J. FROHN ,  Brian Alan LANMAN ,  Anthony B. REED ,  Leslie P. Miranda ,  John G. Allen ,  Alexander J. Pickrell ,  Aaron C. Siegmund ,  Lewis D. Pennington ,  Bryant Yang

IPC: C07K7/08 ,  A61K38/10

CPC classification number: C07K7/08 ,  A61K38/00 ,  A61K38/10 ,  A61K47/542 ,  A61K47/60 ,  C07K14/47 ,  C07K2319/30

Abstract: The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.