公开(公告)号：US10472356B2

公开(公告)日：2019-11-12

申请号：US15554801

申请日：2016-03-02

Applicant: AMGEN INC.

Inventor： Matthew Weiss ,  Benjamin Charles Milgram ,  Thomas Dineen ,  John Stellwagen ,  Angel Guzman-Perez ,  Alessandro Boezio ,  Issac E. Marx

IPC: A61K31/4375 ,  C07D471/04

Abstract: The present invention provides compounds of Formula (I), wherein: as defined in the specification, an enantiomer, diastereomer, atropisomer thereof, or a mixture thereof, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular Nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of sodium channels such as pain disorders, cough, or itch. Also provided are pharmaceutical compositions containing compounds of the present invention.