公开(公告)号：US20230183164A1

公开(公告)日：2023-06-15

申请号：US17920084

申请日：2021-05-04

Applicant: AMGEN INC.

Inventor： Austin G. SMITH ,  Michael T. CORBETT ,  Neil Fred LANGILLE ,  Kyle D. BAUCOM ,  Peter K. DORNAN ,  Gabrielle ST- PIERRE ,  Philipp C. ROOSEN ,  Sheng CUI ,  Roberto PROFETA

IPC: C07C67/62 ,  C07D249/18 ,  C07D519/00 ,  C07D513/08

CPC classification number: C07C67/62 ,  C07D249/18 ,  C07D519/00 ,  C07D513/08 ,  C07B2200/13

Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound F, or a salt thereof, wherein R1 and OPG2 are described herein. Compound F can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.