公开(公告)号：US20180148487A1

公开(公告)日：2018-05-31

申请号：US15578094

申请日：2015-07-31

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Sang Dun CHOI ,  Tae Hyeon YOO ,  Seol Hee PARK

IPC: C07K14/47 ,  C07K7/08 ,  A61P29/00 ,  C07K16/28

CPC classification number: C07K14/4703 ,  A61K38/00 ,  A61P29/00 ,  A61P37/00 ,  C07K7/08 ,  C07K14/47 ,  C07K16/2896

Abstract: The present disclosure relates to a peptide for inhibiting a TLR4 signaling pathway, a TLR4 antagonist including the peptide, and a composition for preventing or treating autoimmune diseases and inflammatory diseases. More specifically, the present disclosure relates to a peptide which binds to a TLR4/MD2 composite to inhibit the secretion of interleukin-6 (IL-6), NO, and ROS, and the activation of NFκB and MAPKs, a TLR4 antagonist including the peptide, and a composition for preventing or treating autoimmune diseases and inflammatory diseases. The peptide according to the present disclosure has an excellent effect of inhibiting the secretion of interleukin-6 (IL-6), NO, and ROS, and the activation of NFκB and MAPKs by inhibiting a TLR4 signaling pathway induced by a liphopolysaccharide (LPS), and thus can be favorably used as a composition for preventing or treating autoimmune diseases and inflammatory diseases occurring by the TLR4 signaling pathway.