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1.发明授权N-2-chlorobenzyl-2-oxo and N-2-chlorobenzyl-2,2-dioxo-1,2,3-oxathiazolidine derivatives, their preparation and synthesis of thieno[3,2-c]pyridine derivatives therefrom 失效N-2-氯苄基-2-氧代和N-2-氯苄基-2,2-二氧代-1,2,3-恶噻唑烷衍生物，由它们制备和合成噻吩并[3,2-c]吡啶衍生物
公开(公告)号：US5342953A
公开(公告)日：1994-08-30
申请号：US648117
申请日：1991-01-31
Applicant: Gary F. Cooper , Keith E. McCarthy
Inventor： Gary F. Cooper , Keith E. McCarthy
IPC: A61K31/435 , A61K31/4365 , A61P7/02 , C07D291/04 , C07D495/04 , C07D241/04
CPC classification number: C07D291/04 , C07D495/04
Abstract: Compounds of the formula: ##STR1## wherein: A is oxo or dioxo;R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen or lower alkyl of one to six carbon atoms;R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are independently hydrogen, lower alkyl of one to six carbon atoms, alkoxy, acyl or halo;are advantageously converted to thieno[3,2-c]pyridine derivatives and the pharmaceutically acceptable salts thereof, particularly ticlopidine hydrochloride.
Abstract translation: 下式的化合物：其中：A是氧代或二氧代; R1，R2和R3独立地是氢或1-6个碳原子的低级烷基; R4，R5，R6和R7独立地为氢，1-6个碳原子的低级烷基，烷氧基，酰基或卤素; 有利地转化为噻吩并[3,2-c]吡啶衍生物及其药学上可接受的盐，特别是噻氯匹定盐酸盐。
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2.发明授权N--2--chlorobenzyl--2--oxo and n--2--chlorobenzyl--2,2--dioxo--1,2,3--oxathiazolidine derivatives, their preparation and synthesis of thieno[3,2--c]pyridine derivatives therefrom 失效N-2-氯苄基-2-氧代和正-2-氯苄基-2,2-二氧代-1,2,3-恶噻唑烷衍生物，由它们制备和合成噻吩并[3,2-c]吡啶衍生物
公开(公告)号：US5516910A
公开(公告)日：1996-05-14
申请号：US245789
申请日：1994-05-19
Applicant: Gary F. Cooper , Keith E. McCarthy
Inventor： Gary F. Cooper , Keith E. McCarthy
IPC: A61K31/435 , A61K31/4365 , A61P7/02 , C07D291/04 , C07D495/04
CPC classification number: C07D291/04 , C07D495/04
Abstract: Compounds of the formula: ##STR1## wherein: A is oxo or dioxo;R.sup.1, R.sup.2 and R.sup.3 are independently hydrogen or lower alkyl of one to six carbon atoms;R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are independently hydrogen, lower alkyl of one to six carbon atoms, alkoxy, acyl or halo;are advantageously converted to thieno[3,2-c]pyridine derivatives and the pharmaceutically acceptable salts thereof, particularly ticlopidine hydrochloride.
Abstract translation: 下式的化合物：其中：A是氧代或二氧代; R1，R2和R3独立地是氢或1-6个碳原子的低级烷基; R4，R5，R6和R7独立地为氢，1-6个碳原子的低级烷基，烷氧基，酰基或卤素; 有利地转化为噻吩并[3,2-c]吡啶衍生物及其药学上可接受的盐，特别是噻氯匹定盐酸盐。
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