公开(公告)号：US20080083671A1

公开(公告)日：2008-04-10

申请号：US11868609

申请日：2007-10-08

申请人： David Bomberger ,  Bryan Chavez ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra ,  Jeffrey Shimon

发明人： David Bomberger ,  Bryan Chavez ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra ,  Jeffrey Shimon

IPC分类号： B01D11/04

CPC分类号： B01D63/02 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3472 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3496 ,  A61M2202/0456 ,  A61M2202/08 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3306 ,  A61M2205/3368 ,  B01D11/0415 ,  B01D11/0457 ,  B01D11/0488 ,  B01D11/0492 ,  B01D61/246 ,  B01D61/36 ,  B01D2317/02 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/10 ,  B01F7/1635 ,  B01F9/02 ,  B01F11/0014 ,  B01F11/0283 ,  B01F2009/0063

摘要： Systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. A fluid is combined with at least one extraction solvent, which causes the lipids to separate from the fluid or from lipid-containing organisms. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to an acceptable concentration enabling the delipidated fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or stored for later use.

摘要翻译： 用于从流体（例如血浆）或从含脂质生物体中除去脂质的系统和方法。 流体与至少一种提取溶剂组合，其引起脂质与流体或含脂质生物分离。 将分离的脂质从流体中除去。 将萃取溶剂从流体中除去或至少降低到可接受的浓度，使得能够将脱脂流体施用于患者，而不会使患者经历不期望的后果。 一旦流体被处理，流体可以被给予捐赠流体的患者给不同的患者，或者存储以供以后使用。

公开(公告)号：US20060000776A1

公开(公告)日：2006-01-05

申请号：US11221617

申请日：2005-09-08

申请人： David Bomberger ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra

发明人： David Bomberger ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra

IPC分类号： B01D11/00

CPC分类号： B01D61/362 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/342 ,  A61M1/3468 ,  A61M1/3472 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3496 ,  A61M1/3693 ,  A61M2202/0456 ,  A61M2202/08 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3368 ,  B01D11/043 ,  B01D11/0492 ,  B01D61/246 ,  B01D63/02 ,  B01D63/046 ,  B01D2313/50

摘要： This invention is directed to systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. These systems contact a fluid with an extraction solvent, which causes the lipids in the fluid to separate from the fluid or causes lipids in the lipid-containing organisms to separate from the lipid-containing organism, using at least one hollow fiber contactor. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to a level below a particular threshold enabling the fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or be stored.

公开(公告)号：US5962364A

公开(公告)日：1999-10-05

申请号：US903054

申请日：1997-07-30

申请人： Robert B. Wilson, Jr. ,  Yuhua Du ,  David Bomberger

发明人： Robert B. Wilson, Jr. ,  Yuhua Du ,  David Bomberger

IPC分类号： C07F17/00 ,  B01J31/00 ,  C07F11/00

CPC分类号： C07F17/00

摘要： A method for converting �MoCp(CO).sub.3 !.sub.2, in which at least one of the Cp groups has a substitutent having a carbonyl or carboxyl group and the compound has a Mo--Mo single bond, into a resinous supported material having repeating units of the formula (MoCp).sub.2 S.sub.4. The repeating units have four bridging sulfido ligands between the two molybdenum atoms, and the repeating units are joined to each other by bridging-sulfide ligands. The method comprises reacting the molybdenum carbonyl dimer with elemental sulfur in a solvent for the starting material at a temperature between 110-120.degree. C. in the presence of a solid adsorbent support. The resinous material may be further hydrogenated, the hydrogenated material may be further reacted to form a material having a carboxyl-containing methanedithiolate ligand, and this latter material may be further hydrolyzed. The molybdenum sulfide dimers are useful for separation, purification, and recovery of unsaturated hydrocarbons.

摘要翻译： 将具有羰基或羧基的取代基中的至少一个具有Mo-Mo单键的化合物的MoCp（CO）3] 2转化为具有重复单元的树脂负载材料的方法 的式（MoCp）2S4。 重复单元在两个钼原子之间具有四个桥连硫基配体，并且重复单元通过桥连硫化物配体彼此连接。 该方法包括在固体吸附剂载体存在下，在110-120℃的温度下使钼羰基二聚体与元素硫在起始物质的溶剂中反应。 可以将树脂材料进一步氢化，氢化材料可以进一步反应以形成具有含羧基的甲硫醚硫酸盐配体的材料，并且后一种材料可以进一步水解。 硫化钼二聚体可用于分离，纯化和回收不饱和烃。

公开(公告)号：US20070246423A1

公开(公告)日：2007-10-25

申请号：US11769872

申请日：2007-06-28

申请人： David Bomberger ,  Bryan Chavez ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra ,  Jeffrey Shimon

发明人： David Bomberger ,  Bryan Chavez ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra ,  Jeffrey Shimon

IPC分类号： B01D17/00

CPC分类号： B01D61/362 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/342 ,  A61M1/3468 ,  A61M1/3472 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3496 ,  A61M1/3693 ,  A61M2202/0456 ,  A61M2202/08 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3368 ,  B01D11/043 ,  B01D11/0492 ,  B01D61/246 ,  B01D63/02 ,  B01D63/046 ,  B01D2313/50

摘要： This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.

摘要翻译： 本发明涉及从流体或诸如血浆的流体中从含脂质生物体中除去脂质的系统和方法。 这些系统将流体与至少一种提取溶剂组合，其引起脂质与流体或含脂质生物分离。 将分离的脂质从流体中除去。 将至少一种提取溶剂从流体中除去或者至少减少到使得能够向患者施用流体的浓度，而不会产生不期望的后果。 一旦流体被处理，流体可以被施用给捐赠流体的患者或不同的患者进行治疗。

公开(公告)号：US20070181485A1

公开(公告)日：2007-08-09

申请号：US11737939

申请日：2007-04-20

申请人： David Bomberger ,  Bryan Chavez ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra ,  Jeffrey Shimon

发明人： David Bomberger ,  Bryan Chavez ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra ,  Jeffrey Shimon

IPC分类号： C02F1/44

CPC分类号： B01D61/362 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/342 ,  A61M1/3472 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3496 ,  A61M1/3693 ,  A61M2202/0456 ,  A61M2202/08 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3306 ,  A61M2205/3331 ,  A61M2205/3334

摘要： This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.

摘要翻译： 本发明涉及从流体或诸如血浆的流体中从含脂质生物体中除去脂质的系统和方法。 这些系统将流体与至少一种提取溶剂组合，其引起脂质与流体或含脂质生物分离。 将分离的脂质从流体中除去。 将至少一种提取溶剂从流体中除去或者至少减少到使得能够向患者施用流体的浓度，而不会产生不期望的后果。 一旦流体被处理，流体可以被施用给捐赠流体的患者或不同的患者进行治疗。

公开(公告)号：US20070039887A1

公开(公告)日：2007-02-22

申请号：US11589376

申请日：2006-10-30

申请人： David Bomberger ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra

发明人： David Bomberger ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra

IPC分类号： B01D61/00

CPC分类号： B01D61/362 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/342 ,  A61M1/3468 ,  A61M1/3472 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3496 ,  A61M1/3693 ,  A61M2202/0456 ,  A61M2202/08 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3368 ,  B01D11/043 ,  B01D11/0492 ,  B01D61/246 ,  B01D63/02 ,  B01D63/046 ,  B01D2313/50

摘要： This invention is directed to systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. These systems contact a fluid with an extraction solvent, which causes the lipids in the fluid to separate from the fluid or causes lipids in the lipid-containing organisms to separate from the lipid-containing organism, using at least one hollow fiber contactor. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to a level below a particular threshold enabling the fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or be stored.

摘要翻译： 本发明涉及从流体（例如血浆）或从含脂质生物体中除去脂质的系统和方法。 这些系统与提取溶剂接触流体，其使得流体中的脂质与流体分离，或者使用至少一个中空纤维接触器使含脂质生物体中的脂质与含脂质生物体分离。 将分离的脂质从流体中除去。 将萃取溶剂从流体中除去或至少降低到低于特定阈值的水平，使得能够将流体施用于患者，而患者不经历不期望的后果。 一旦液体已经被处理，流体可以被给予捐赠流体的患者，给不同的患者或被储存。

公开(公告)号：US20050133450A1

公开(公告)日：2005-06-23

申请号：US11059064

申请日：2005-02-16

申请人： David Bomberger ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra

发明人： David Bomberger ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra

IPC分类号： A61M1/34 ,  B01D61/36 ,  C02F1/44

CPC分类号： B01D61/362 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/341 ,  A61M1/342 ,  A61M1/3468 ,  A61M1/3472 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3496 ,  A61M1/3693 ,  A61M2202/0456 ,  A61M2202/08 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3368 ,  B01D11/043 ,  B01D11/0492 ,  B01D61/246 ,  B01D63/02 ,  B01D63/046 ,  B01D2313/50

摘要： This invention is directed to systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. These systems contact a fluid with an extraction solvent, which causes the lipids in the fluid to separate from the fluid or causes lipids in the lipid-containing organisms to separate from the lipid-containing organism, using at least one hollow fiber contactor. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to a level below a particular threshold enabling the fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or be stored.

摘要翻译： 本发明涉及从流体（例如血浆）或从含脂质生物体中除去脂质的系统和方法。 这些系统与提取溶剂接触流体，其使得流体中的脂质与流体分离，或者使用至少一个中空纤维接触器使含脂质生物体中的脂质与含脂质生物体分离。 将分离的脂质从流体中除去。 将萃取溶剂从流体中除去或至少降低到低于特定阈值的水平，使得能够将流体施用于患者，而患者不经历不期望的后果。 一旦液体已经被处理，流体可以被给予捐赠流体的患者，给不同的患者或被储存。

公开(公告)号：US20050016912A1

公开(公告)日：2005-01-27

申请号：US10857534

申请日：2004-05-28

申请人： David Bomberger ,  Bryan Chavez ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra ,  Jeffrey Shimon

发明人： David Bomberger ,  Bryan Chavez ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra ,  Jeffrey Shimon

IPC分类号： A61M1/34 ,  B01D61/36 ,  B01D63/04

CPC分类号： B01D61/362 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/342 ,  A61M1/3472 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3496 ,  A61M1/3693 ,  A61M2202/0456 ,  A61M2202/08 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3306 ,  A61M2205/3331 ,  A61M2205/3334

摘要： This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.

摘要翻译： 本发明涉及从流体或诸如血浆的流体中从含脂质生物体中除去脂质的系统和方法。 这些系统将流体与至少一种提取溶剂组合，其引起脂质与流体或含脂质生物分离。 将分离的脂质从流体中除去。 将至少一种提取溶剂从流体中除去或者至少减少到使得能够向患者施用流体的浓度，而不会产生不期望的后果。 一旦流体被处理，流体可以被施用给捐赠流体的患者或不同的患者进行治疗。

公开(公告)号：US20070138094A1

公开(公告)日：2007-06-21

申请号：US11700626

申请日：2007-01-31

申请人： David Bomberger ,  Bryan Chavez ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra ,  Jeffrey Shimon

发明人： David Bomberger ,  Bryan Chavez ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra ,  Jeffrey Shimon

IPC分类号： B01D61/24

CPC分类号： B01D63/02 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3472 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3496 ,  A61M2202/0456 ,  A61M2202/08 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3306 ,  A61M2205/3368 ,  B01D11/0415 ,  B01D11/0457 ,  B01D11/0488 ,  B01D11/0492 ,  B01D61/246 ,  B01D61/36 ,  B01D2317/02 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/10 ,  B01F7/1635 ,  B01F9/02 ,  B01F11/0014 ,  B01F11/0283 ,  B01F2009/0063

摘要： Systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. A fluid is combined with at least one extraction solvent, which causes the lipids to separate from the fluid or from lipid-containing organisms. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to an acceptable concentration enabling the delipidated fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or stored for later use.

公开(公告)号：US20060060520A1

公开(公告)日：2006-03-23

申请号：US11263819

申请日：2005-11-01

申请人： David Bomberger ,  Bryan Chavez ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra ,  Jeffrey Shimon

发明人： David Bomberger ,  Bryan Chavez ,  Pablo Garcia ,  Eric Hegwer ,  Thomas Low ,  Ripudaman Malhotra ,  Jeffrey Shimon

IPC分类号： B01D63/02

CPC分类号： B01D63/02 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3472 ,  A61M1/3482 ,  A61M1/3486 ,  A61M1/3496 ,  A61M2202/0456 ,  A61M2202/08 ,  A61M2202/203 ,  A61M2202/206 ,  A61M2205/3306 ,  A61M2205/3368 ,  B01D11/0415 ,  B01D11/0457 ,  B01D11/0488 ,  B01D11/0492 ,  B01D61/246 ,  B01D61/36 ,  B01D2317/02 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/10 ,  B01F7/1635 ,  B01F9/02 ,  B01F11/0014 ,  B01F11/0283 ,  B01F2009/0063

摘要： Systems and methods for removing lipids from a fluid, such as plasma, or from lipid-containing organisms. A fluid is combined with at least one extraction solvent, which causes the lipids to separate from the fluid or from lipid-containing organisms. The separated lipids are removed from the fluid. The extraction solvent is removed from the fluid or at least reduced to an acceptable concentration enabling the delipidated fluid to be administered to a patient without the patient experiencing undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid, to a different patient, or stored for later use.