公开(公告)号：US09169232B2

公开(公告)日：2015-10-27

申请号：US14344644

申请日：2012-09-14

申请人： Sanjay Sukumar Saralaya ,  Akshaya Kunjyannaya ,  Shashiprabha ,  Shridhara Kanakamajalu ,  Kothapalli Sundarraja Rao ,  Kuppuswamy Nagarajan

发明人： Sanjay Sukumar Saralaya ,  Akshaya Kunjyannaya ,  Shashiprabha ,  Shridhara Kanakamajalu ,  Kothapalli Sundarraja Rao ,  Kuppuswamy Nagarajan

IPC分类号： C07D317/36 ,  C07D317/40

CPC分类号： C07D317/36 ,  C07D317/40

摘要： The present invention relates to atovaquone prodrug compound of formula (I). Accordingly, present invention provides a process involving condensation of Atovaquone (II) with 5-methyl-4-chloromethyl dioxalone (III) in suitable solvent system and optionally followed by distillation and crystallization to provide Atovaquone prodrug compound of formula (I) in high yields, purity, and suitable for large-scale manufacture.

摘要翻译： 本发明涉及式（I）的阿托伐醌前药化合物。 因此，本发明提供了一种方法，该方法包括将Atovaquone（II）与5-甲基-4-氯甲基二环（III）在合适的溶剂体系中缩合，任选地随后进行蒸馏和结晶，以高产率提供式（I）的阿托伐醌前药化合物 ，纯度高，适合大规模生产。

公开(公告)号：US20140343297A1

公开(公告)日：2014-11-20

申请号：US14344644

申请日：2012-09-14

申请人： Sanjay Sukumar Saralaya ,  Akshaya Kunjyannaya ,  (none) Shashiprabha ,  Shridhara Kanakamajalu ,  Kothapalli Sundarraja Rao ,  Kuppuswamy Nagarajan

发明人： Sanjay Sukumar Saralaya ,  Akshaya Kunjyannaya ,  (none) Shashiprabha ,  Shridhara Kanakamajalu ,  Kothapalli Sundarraja Rao ,  Kuppuswamy Nagarajan

IPC分类号： C07D317/36

CPC分类号： C07D317/36 ,  C07D317/40

摘要： The present invention relates to atovaquone prodrug compound of formula (I). Accordingly, present invention provides a process involving condensation of Atovaquone (II) with 5-methyl-4-chloromethyl dioxalone (III) in suitable solvent system and optionally followed by distillation and crystallization to provide Atovaquone prodrug compound of formula (I) in high yields, purity, and suitable for large-scale manufacture.

摘要翻译： 本发明涉及式（I）的阿托伐醌前药化合物。 因此，本发明提供了一种方法，该方法包括将Atovaquone（II）与5-甲基-4-氯甲基二环（III）在合适的溶剂体系中缩合，任选地随后进行蒸馏和结晶，以高产率提供式（I）的阿托伐醌前药化合物 ，纯度高，适合大规模生产。