- 专利标题： Methods of treating tissue calcification
-
申请号： US17111156申请日： 2020-12-03
-
公开(公告)号： USRE49529E1公开(公告)日： 2023-05-16
- 发明人: Anthony Quinn , Nelson Hsia , Tayeba Khan , Kim Lynette Askew , Gregory Grabowski , Zhiliang Cheng , W. Charles O'Neill
- 申请人： Inozyme Pharma, Inc.
- 申请人地址： US MA Boston
- 专利权人： Inozyme Pharma, Inc.
- 当前专利权人： Inozyme Pharma, Inc.
- 当前专利权人地址： US MA Boston
- 代理机构： Nutter McClennen & Fish LLP
- 国际申请： PCT/US2015/066646 2015.12.18
- 国际公布： WO2016/100803A 2016.06.23
- 进入国家日期： 2017-06-16
- 主分类号： C12N9/16
- IPC分类号： C12N9/16 ; A61K38/46 ; C12N9/14 ; A61P3/00 ; A61P9/00 ; A61P13/12
摘要：
The present invention provides a method of treating NPP1 deficiency or NPP1-associated disease such as idiopathic infantile arterial calcification (IIAC), pseudoxanthoma elasticum, vascular calcification in chronic kidney disease (VCCKD), insulin resistance, hypophosphatemic rickets, myocardial ischemia, joint calcification, angioid streaks, and ossification of the posterior longitudinal ligament of the spine. The present invention provides a method for treating tissue calcification by administering soluble NPP1 to produce a transient increase in serum pyrophosphate levels.
信息查询
