再颁专利
- 专利标题: Potent inducers of terminal differentiation and methods of use thereof
- 专利标题(中): 终末分化的潜在诱导剂及其使用方法
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申请号: US10004411申请日: 2001-11-02
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公开(公告)号: USRE38506E1公开(公告)日: 2004-04-20
- 发明人: Ronald Breslow , Paul A. Marks , Richard A. Rifkind , Branko Jursic
- 申请人: Ronald Breslow , Paul A. Marks , Richard A. Rifkind , Branko Jursic
- 主分类号: A01N4340
- IPC分类号: A01N4340
摘要:
The present invention provides the compound having the structure: wherein each of R1 and R2 are independently the same as or different from each other; when R1 and R2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R1 and R2 are different, R1=R3—N—R4, wherein each of R3 and R4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R3 and R4 bond together to form a piperidine group and R2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8. The present invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition and a therapeutically acceptable amount of the compound above.
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