- 专利标题： Broad spectrum conjugate vaccine to prevent Klebsiella pneumoniae and Pseudomonas aeruginosa infections
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申请号： US15509041申请日： 2015-09-18
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公开(公告)号： US09988426B2公开(公告)日： 2018-06-05
- 发明人: Raphael Simon , Alan Cross , Sharon Tennant
- 申请人： Raphael Simon , Alan Cross , Sharon Tennant
- 申请人地址： US MD Baltimore
- 专利权人： UNIVERSITY OF MARYLAND, BALTIMORE
- 当前专利权人： UNIVERSITY OF MARYLAND, BALTIMORE
- 当前专利权人地址： US MD Baltimore
- 代理机构： Nevrivy Patent Law Group P.L.L.C.
- 国际申请： PCT/US2015/051032 WO 20150918
- 国际公布： WO2016/044773 WO 20160324
- 主分类号： C07K14/21
- IPC分类号： C07K14/21 ; C07K14/26 ; A61K39/104 ; A61K39/108 ; A61K47/48 ; A61K39/00
摘要：
The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked to one or more Klebsiella surface polysaccharide antigens, such as Klebsiella pneumoniae O polysaccharide from serovars O1, O2a, O2a,c, O3, O4, O5, O7, O8 and 012. The present invention also provides serovar reagent strains to produce the conjugates and vaccine compositions and methods of inducing an immune response with the conjugates and vaccine compositions.
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