Disclosed in an embodiment of the disclosure is an interference rejection combining (IRC) method supporting transmit diversity, in which an N*N interference and noise covariance matrix corresponding to one subcarrier is generated from signals, in a transmit diversity mode, received at cell reference signal (CRS) resource positions via N receiving antennas, where N is greater than or equal to 3; Cholescy decomposition and upper triangular matrix inversion is performed on the N*N interference and noise covariance matrix to obtain an N*N block matrix; the N*N block matrix is expanded to a 2N*2N noise whitening matrix; and the received signals and channel estimation values are whitened according to the noise whitening matrix, and the whitened received signals and channel estimation values used to obtain a minimum mean square error-IRC (MMSE-IRC) processing result. Also disclosed are an IRC device supporting the transmit diversity, and a computer storage medium.