Systems and method for ultrasound probe guidance are provided. One system includes a probe guide with a body having at least one engagement portion for coupling an ultrasound probe to the body. The system also includes at least one sensor configured to communicate with an ultrasound imaging system, wherein the at least one sensor coupled to the body and configured to determine at least one of a spatial position, an orientation, a probe head movement speed, a temperature, a scan speed of the body relative to an object being scanned, or a contact pressure relative to the body and the object being scanned.