Invention Grant
- Patent Title: Control of protein glycosylation by culture medium supplementation and cell culture process parameters
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Application No.: US15000522Application Date: 2016-01-19
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Publication No.: US09944968B2Publication Date: 2018-04-17
- Inventor: William Yang , Yao-Ming Huang , Kyle McElearney , Lia Tescione , James Lambropoulos , An Zhang , Valerie Tsang , Thomas Ryll , Sangil Lee , Dae Sung Lee
- Applicant: Biogen MA Inc. , Samsung Bioepis
- Applicant Address: US MA Cambridge KR
- Assignee: Biogen MA Inc.,Samsung Bioepis
- Current Assignee: Biogen MA Inc.,Samsung Bioepis
- Current Assignee Address: US MA Cambridge KR
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C12N5/18
- IPC: C12N5/18 ; C12P21/00 ; C12N5/00
Abstract:
The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
Public/Granted literature
- US20160304928A1 Control of Protein Glycosylation by Culture Medium Supplementation and Cell Culture Process Parameters Public/Granted day:2016-10-20
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