- 专利标题: Antidiabetic tricyclic compounds
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申请号: US15023124申请日: 2014-09-30
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公开(公告)号: US09932311B2公开(公告)日: 2018-04-03
- 发明人: Tesfaye Biftu , Purakkattle Biju , Steven L. Colletti , Mingxiang Cui , William K. Hagmann , Bin Hu , Hubert Josien , Nam Fung Kar , Anilkumar Nair , Ravi Nargund , Donald M. Sperbeck , Cheng Zhu
- 申请人: Merck Sharp & Dohme Corp.
- 申请人地址: US NJ Rahway
- 专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人: Merck Sharp & Dohme Corp.
- 当前专利权人地址: US NJ Rahway
- 代理商 Baerbel R. Brown; Catherine D. Fitch
- 优先权: WOPCT/CN2013/084846 20131008
- 国际申请: PCT/CN2014/087857 WO 20140930
- 国际公布: WO2015/051725 WO 20150416
- 主分类号: C07D221/16
- IPC分类号: C07D221/16 ; C07D401/12 ; C07D405/12 ; C07D405/14 ; A61K31/435 ; A61K31/444 ; A61K45/06
摘要:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
公开/授权文献
- US20160207887A1 ANTIDIABETIC TRICYCLIC COMPOUNDS 公开/授权日:2016-07-21
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