发明授权
- 专利标题: Non-aqueous patch
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申请号: US15646744申请日: 2017-07-11
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公开(公告)号: US09931403B2公开(公告)日: 2018-04-03
- 发明人: Tatsuya Mori , Naoyuki Saida
- 申请人: Itochu Chemical Frontier Corporation , Oishi Koseido Co., Ltd.
- 申请人地址: JP Tokyo JP Saga
- 专利权人: Itochu Chemical Frontier Corporation,Oishi Koseido Co., Ltd.
- 当前专利权人: Itochu Chemical Frontier Corporation,Oishi Koseido Co., Ltd.
- 当前专利权人地址: JP Tokyo JP Saga
- 代理商 G. Kenneth Smith
- 主分类号: A61K47/12
- IPC分类号: A61K47/12 ; A61K9/70 ; A61K31/167
摘要:
Non-aqueous patches comprising lidocaine, which is not dissolved and is present in a crystalline state, have poor permeability to the skin. Therefore, non-aqueous patches have a high concentration of lidocaine. It is pointed out that lidocaine has an adverse effect on the heart. Prolonged use of a high concentration of lidocaine causes side effects, such as shock, rubor, and irritating sensation. External preparations comprising more than 5 mass % of lidocaine are designated as powerful drugs, and cannot be used as household (nonprescription) medicine. Provided is a non-aqueous patch that is effective to relieve muscle pain, the non-aqueous patch comprising lidocaine and/or its reactant, and a dissolving agent composed of an organic acid and a polyalcohol, which are contained in a base.
公开/授权文献
- US20170304449A1 NON-AQUEOUS PATCH 公开/授权日:2017-10-26
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