A device providing an indication of eye disease in a patient comprises a light emitter; an optical assembly arranged so that light emitted from the light emitter reaches an eye of the patient; a camera arranged to image the eye of the patient; and a controller. The controller measures the eye's pupil area using images received from the camera and adjusts the luminance of the light emitted from the light emitter as a non-constant function of the eye's pupil area so as to create a plurality of stimulus intervals. At least two of the stimulus intervals differ in their average retinal illuminance. The controller analyzes the pupil measurements and/or an electrical response in at least two of the stimulus intervals to provide an indication of eye disease based. In some embodiments, the patient's age is also used in the analysis. Methods of using said device are also contemplated.