Systems and methods are disclosed for weighting the image quality prediction of any visual-attention-agnostic quality metric with a saliency map. By accounting for the salient regions of an image or video frame, the disclosed systems and methods may dramatically improve the precision of the visual-attention-agnostic quality metric during image or video quality assessment. In one implementation, a method of saliency-weighted video quality assessment includes: determining a per-pixel image quality vector of an encoded video frame; determining per-pixel saliency values of the encoded video frame or a reference video frame corresponding to the encoded video frame; and computing a saliency-weighted image quality metric of the encoded video frame by weighting the per-pixel image quality vector using the per-pixel saliency values.