- 专利标题： Composition containing polycationic triblock copolymer, polyanionic polymer and physiologically active peptide
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申请号： US14896952申请日： 2014-06-10
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公开(公告)号： US09918935B2公开(公告)日： 2018-03-20
- 发明人: Yukio Nagasaki , Junya Kaneko , Toru Yoshitomi , Shiro Ishii
- 申请人： UNIVERSITY OF TSUKUBA
- 申请人地址： JP Ibaraki
- 专利权人： UNIVERSITY OF TSUKUBA, A JAPANESE NATIONAL UNIVERSITY
- 当前专利权人： UNIVERSITY OF TSUKUBA, A JAPANESE NATIONAL UNIVERSITY
- 当前专利权人地址： JP Ibaraki
- 代理机构： Wenderoth, Lind & Ponack, L.L.P.
- 优先权： JP2013-123001 20130611
- 国际申请： PCT/JP2014/065344 WO 20140610
- 国际公布： WO2014/199982 WO 20141218
- 主分类号： A61K9/107
- IPC分类号： A61K9/107 ; A61K38/44 ; A61K38/28 ; A61K38/38 ; C08F293/00 ; C08F12/18 ; A61K9/00 ; C08L53/00 ; A61K47/32 ; A61K38/00 ; A61K47/34
摘要：
[Problem] To provide a physiologically active peptide-loaded stable composition for injection into living bodies.[Solution] A composition containing a triblock copolymer represented by formula (I), a polyanionic polymer and a physiologically active peptide: CNR-PEG-CNR (I) in the formula, CNR moieties are each independently a polymer segment containing a repeating unit that contains, as a part of a pendant group, a cyclic nitroxide radical bonded to a main polymer chain via a linking group that contains at least one amino group, and PEG is a segment that contains poly(ethylene glycol).
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