An “operate with missing region” feature allows a cluster to continue servicing reads for available regions even when some regions are missing. Upon a given node failure condition, the cluster is placed in an effective read-only mode for all regions. The node failure condition typically is one where there has been a failure of an authoritative region copy and no backup copy is then available. Typically, “read-only” means no client write or update requests succeed while the cluster is in this state. Those requests should fail with an error message that indicates failure because of the read-only status. Preferably, such requests are re-tried. In this mode, regions are only allowed to perform read operations but the cluster continues to operate with missing regions, and missing regions are entered on a region map. The cluster then automatically recovers returning missing regions, after which it leaves the read-only state.