- 专利标题： Applications of substituent benzyloxy group containing ether compounds for preparing antitumor drugs
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申请号： US14909124申请日： 2014-08-22
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公开(公告)号： US09895346B2公开(公告)日： 2018-02-20
- 发明人: Changling Liu , Aiying Guan , Xiaoping Yang , Baoshan Chai
- 申请人： Sinochem Corporation , Shenyang Research Institute Of Chemical Industry Co., Ltd.
- 申请人地址： CN Beijing CN Shenyang
- 专利权人： Sinochem Corporation,Shenyang Research Institute of Chemical Industry Co., Ltd.
- 当前专利权人： Sinochem Corporation,Shenyang Research Institute of Chemical Industry Co., Ltd.
- 当前专利权人地址： CN Beijing CN Shenyang
- 代理机构： Canady + Lortz LLP
- 代理商 Suzannah K. Sundby, Esq.
- 优先权： CN201310377438 20130827; CN201310377457 20130827
- 国际申请： PCT/CN2014/084990 WO 20140822
- 国际公布： WO2015/027863 WO 20150305
- 主分类号： A61K31/366
- IPC分类号： A61K31/366 ; A61K31/415 ; A61K31/505 ; A61K31/216
摘要：
Disclosed are applications of substituent benzyloxy group containing ether compounds represented by general formula I for preparing antitumor drugs. The definition of the substituent groups in the formula I are provided in the specification.The compounds having general formula I have desirable antitumor activity, particularly, and have excellent activity against leukemia strain HL-60, lung cancer A549, H157, H460, H520, bladder cancer T24, J82, prostate cancer LNCap, PC-3, rectal cancer HCT8, HCT116, RkO and the like.
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