- 专利标题: Infusion preparation
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申请号: US15627783申请日: 2017-06-20
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公开(公告)号: US09884149B2公开(公告)日: 2018-02-06
- 发明人: Seiji Tani , Yasuhiro Mitsumoto
- 申请人: OTSUKA PHARMACEUTICAL FACTORY, INC.
- 申请人地址: JP Naruto-Shi
- 专利权人: OTSUKA PHARMACEUTICAL FACTORY, INC.
- 当前专利权人: OTSUKA PHARMACEUTICAL FACTORY, INC.
- 当前专利权人地址: JP Naruto-Shi
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2010-265611 20101129
- 主分类号: A61K31/07
- IPC分类号: A61K31/07 ; A61M5/14 ; A61K9/00 ; A61K31/675 ; A61K31/519 ; A61K31/525 ; A61K31/51 ; A61K31/7004 ; A61K36/48 ; A61K31/685 ; A61K31/4172 ; A23L33/15 ; A23L33/115 ; A23L33/175 ; A23L33/125
摘要:
An object of the present invention is to provide an infusion preparation in which the Maillard reaction between an amino acid and a reducing sugar does not occur during storage and the size of fat particles in the fat emulsion does not increase during storage, and in which various types of vitamins can be incorporated in a stable manner, in spite of the fact that it is a two-chamber infusion preparation. Furthermore, even if only one of the infusions (of the infusion preparation) is administered, the patient is unlikely to develop hyperkalemia, vascular pain, or phlebitis. The present invention provides an infusion preparation containing two chambers separated by a partition that can be communicably opened, wherein a first chamber contains a first-chamber infusion containing a sugar and a fat emulsion, a second chamber contains a second-chamber infusion containing an amino acid and an electrolyte, the first-chamber infusion is substantially free of potassium, and has a relative osmotic pressure of 2.0 to 3.0, the second-chamber infusion has a potassium concentration of 40 mEq/L or less and a relative osmotic pressure of 2.5 to 3.5, and a mixture of the first- and second-chamber infusions has a potassium concentration of 16 mEq/L or more as measured upon communicably opening the partition.
公开/授权文献
- US20170304530A1 INFUSION PREPARATION 公开/授权日:2017-10-26
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