- 专利标题： NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation
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申请号： US14434573申请日： 2013-10-09
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公开(公告)号： US09877981B2公开(公告)日： 2018-01-30
- 发明人: David A. Sinclair , Ana P. Gomes , Lindsay Wu
- 申请人： President and Fellows of Harvard College , NewSouth Innovations Pty Limited
- 申请人地址： US MA Cambridge AU Sydney
- 专利权人： President and Fellows of Harvard College,NewSouth Innovations Pty Limited
- 当前专利权人： President and Fellows of Harvard College,NewSouth Innovations Pty Limited
- 当前专利权人地址： US MA Cambridge AU Sydney
- 代理机构： Wolf, Greenfield & Sacks, P.C.
- 国际申请： PCT/US2013/064154 WO 20131009
- 国际公布： WO2014/059034 WO 20140417
- 主分类号： A01N43/04
- IPC分类号： A01N43/04 ; A61K31/70 ; A61K31/7064 ; A61K38/45 ; A61K48/00 ; A61K31/706
摘要：
Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to hypoxia and the extension of life span. Also described herein are methods for the identification of agents useful in the foregoing methods.Methods and compositions are provided for the treatment of diseases or disorders associated with mitochondrial dysfunction.The invention relates to methods for treatment and prevention of cancer by administering agents that increase levels of NAD+, such as NAD+ precursors or agents involved in NAD+ biosynthesis.
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