- 专利标题： Thiazoles as modulators of RORγt
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申请号： US14927501申请日： 2015-10-30
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公开(公告)号： US09861618B2公开(公告)日： 2018-01-09
- 发明人: Steven Goldberg , Christoph Steeneck , Christian Gege , Olaf Kinzel , Gerald Kleymann , Thomas Hoffmann
- 申请人： Janssen Pharmaceutica NV
- 申请人地址： BE Beerse
- 专利权人： Janssen Pharmaceutica NV
- 当前专利权人： Janssen Pharmaceutica NV
- 当前专利权人地址： BE Beerse
- 代理商 Yuriy P. Stercho
- 主分类号： A61K31/426
- IPC分类号： A61K31/426 ; C07D417/04 ; A61K31/427 ; A61K45/06 ; C07D417/14 ; A61K31/5377 ; A61K31/4725 ; A61K31/454 ; A61K31/433 ; C07D277/30 ; A61K31/506
摘要：
The present invention comprises compounds of Formula I wherein: R1, R2, R3, R4, R5, R7, R8, and are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein the syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.
公开/授权文献
- US20160120850A1 THIAZOLES AS MODULATORS OF RORyt 公开/授权日：2016-05-05
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