A method and system of managing a chain of custody for cannabis is provided that includes depositing one or more identification tags onto the surface of one or more cannabis seeds at a first custodian location, and depositing the identification tags onto the surface of one or more cannabis, wherein the cannabis plants are grown and matured from the cannabis seeds. The method and system further includes receiving the tagged cannabis plants at a second custodian location and extracting cannabinoids from the tagged cannabis plants, wherein the extracted cannabinoids include the one or more identification tags. In addition, the method and system further includes receiving the extracted cannabinoids at a third custodian location, wherein the extracted cannabinoids include the one or more identification tags which may be accumulated from all the prior custodians.