The embodiments herein relate to a method in a first network node (301) for handling Automatic Gain Control, AGC, scaling and Transmit Power Control, TPC, scaling of a signal received from a second network node (305). The first network node AGC compensates the signal for any AGC scaling changes. The AGC compensating the signal results in an AGC compensated signal comprising a constant AGC scaling. The first network node detects a TPC scaling change of the signal. The detection is based on the signal after the TPC scaling change and based on a predicted channel estimate. The predicted channel estimate is based on the signal before the TPC scaling change. The first network node TPC compensates for the detected TPC scaling change. The TPC compensation results in an AGC and TPC compensated signal comprising the constant AGC scaling and a constant TPC scaling according to the detected TPC scaling change.