- 专利标题: Biphenyl derivatives and methods for preparing same
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申请号: US14909096申请日: 2014-07-17
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公开(公告)号: US09828339B2公开(公告)日: 2017-11-28
- 发明人: Soon-Hoe Kim , Weon-Bin Im , Chong-Hwan Cho , Sun-Ho Choi , Jung-Sang Park , Mi-Yeon Kim , Sung-Hak Choi , Min-Jung Lee , Kang-Hun Cho
- 申请人: DONG-A ST CO., LTD
- 申请人地址: KR Seoul
- 专利权人: DONG-A ST CO., LTD
- 当前专利权人: DONG-A ST CO., LTD
- 当前专利权人地址: KR Seoul
- 代理机构: Dentons US LLP
- 代理商 Stephanie Seidman; Frank J. Miskiel
- 优先权: KR10-2013-0090175 20130730
- 国际申请: PCT/KR2014/006483 WO 20140717
- 国际公布: WO2015/016511 WO 20150205
- 主分类号: C07D207/08
- IPC分类号: C07D207/08
摘要:
Provided are biphenyl derivatives having the structure of Formula 1: stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen, halogen, hydroxy, substituted or unsubstituted C1-C6 alkyl, or C1-C6 alkoxy; R2, R3 and R4 are each independently hydrogen, halogen, substituted or unsubstituted amino, nitro, cyano, hydroxy, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 alkoxy, or —C(O)R6; R5 is hydrogen or C1-C6 alkyl; n is 0 or 1; and R6 is hydrogen or amino, methods for preparing the same, and a pharmaceutical composition containing the same. The biphenyl derivatives having the structure of Formula 1 act as muscarinic M3 receptor antagonists, and thus are useful for the prevention or treatment of a disease selected from among chronic obstructive pulmonary disease, asthma, irritable bowel syndrome, urinary incontinence, rhinitis, spasmodic colitis, chronic cystitis, Alzheimer's disease, senile dementia, glaucoma, schizophrenia, gastroesophageal reflux disease, cardiac arrhythmia, and hyper-salivation syndromes.
公开/授权文献
- US20160176816A1 NOVEL BIPHENYL DERIVATIVE AND METHOD FOR PREPARING SAME 公开/授权日:2016-06-23
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