Systems and methods for separating carbon dioxide (CO2) from a gas stream are provided. The system includes a reaction chamber 20, a pressurization unit 30, and a desorption unit 40. The reaction chamber 20 is configured to receive a liquid sorbent stream 14 and the gas stream 12, to react at least a portion of CO2 in the gas stream 12 with the liquid sorbent and form an adduct stream 22. The pressurization unit 30 is configured to contact the adduct stream 22 with a pressurized CO2 stream 24 and form a pressurized adduct stream 32 that includes a liquid CO2 adduct. The desorption unit 40 is in fluid communication with the pressurization unit 30, and is configured to decompose at least a portion of the liquid CO2 adduct to form a CO2 stream 42 and a regenerated liquid sorbent stream 44.