Invention Grant
- Patent Title: Recombinant strain producing L-amino acids, constructing method therefor and method for producing L-amino acids
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Application No.: US14891622Application Date: 2015-02-04
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Publication No.: US09796991B2Publication Date: 2017-10-24
- Inventor: Tingyi Wen , Xiuling Shang , Yun Zhang , Shuwen Liu , Yong Liang , Yu Zhang
- Applicant: INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES
- Applicant Address: CN Beijing
- Assignee: INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES
- Current Assignee: INSTITUTE OF MICROBIOLOGY, CHINESE ACADEMY OF SCIENCES
- Current Assignee Address: CN Beijing
- Agency: Howard IP Law Office, PA
- Priority: CN201410050868 20140214
- International Application: PCT/CN2015/072220 WO 20150204
- International Announcement: WO2015/120775 WO 20150820
- Main IPC: C12P13/04
- IPC: C12P13/04 ; C12P13/24 ; C12N9/04 ; C12N9/92 ; C12N15/77
Abstract:
The present invention relates to recombinant bacteria producing L-amino acid, in which the recombinant bacteria has reduced expression of the glucose-6-phosphate isomerase gene pgi and improved expression of the glucose-6-phosphate dehydrogenase gene -opcA than the starting bacteria, where the starting bacterium is a bacterial strain that can accumulate target amino acid(s) and preferably, the amino acid is L-histidine.
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